Immunogenetics

, Volume 57, Issue 9, pp 628–635

Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients

Authors

  • Milena Nasi
    • Department of Biomedical Sciences, Chair of ImmunologyUniversity of Modena and Reggio Emilia
  • Marcello Pinti
    • Department of Biomedical Sciences, Chair of ImmunologyUniversity of Modena and Reggio Emilia
  • Roberto Bugarini
    • Department of Biomedical Sciences, Chair of ImmunologyUniversity of Modena and Reggio Emilia
  • Leonarda Troiano
    • Department of Biomedical Sciences, Chair of ImmunologyUniversity of Modena and Reggio Emilia
  • Enrico Lugli
    • Department of Biomedical Sciences, Chair of ImmunologyUniversity of Modena and Reggio Emilia
  • Cristian Bellodi
    • Department of Biomedical Sciences, Chair of ImmunologyUniversity of Modena and Reggio Emilia
    • MRC Toxicology Unit, Section of Genetic InstabilityUniversity of Leicester
  • Cristina Mussini
    • Department of Medical and Surgical Specialties, Clinic of Infectious and Tropical DiseasesUniversity of Modena and Reggio Emilia and Azienda Policlinico
  • Vanni Borghi
    • Department of Medical and Surgical Specialties, Clinic of Infectious and Tropical DiseasesUniversity of Modena and Reggio Emilia and Azienda Policlinico
  • Tommaso Trenti
    • Clinical Pathology ServicePavullo Hospital
  • Fiorella Balli
    • Department of PediatricsUniversity of Modena and Reggio Emilia
  • Roberto Esposito
    • Department of Medical and Surgical Specialties, Clinic of Infectious and Tropical DiseasesUniversity of Modena and Reggio Emilia and Azienda Policlinico
    • Department of Biomedical Sciences, Chair of ImmunologyUniversity of Modena and Reggio Emilia
    • Department of Biomedical Sciences, Section of General Pathology
Original Paper

DOI: 10.1007/s00251-005-0031-z

Cite this article as:
Nasi, M., Pinti, M., Bugarini, R. et al. Immunogenetics (2005) 57: 628. doi:10.1007/s00251-005-0031-z

Abstract

Fas and Fas ligand (FasL) are the main genes that control cell death in the immune system. Indeed, they are crucial for the regulation of T lymphocyte homeostasis because they can influence cell proliferation. A strong debate exists on the importance of Fas/FasL system during HIV infection, which is characterized by the loss of CD4+ T cells directly, or indirectly, caused by the virus. To investigate whether the genetic background of the host plays a role in the immunoreconstitution, we studied the influence of different Fas and FasL polymorphisms on CD4+ T lymphocyte count and plasma viral load following initiation of highly active antiretroviral therapy (HAART) in drug-naïve HIV+ patients. We studied 131 individuals, who were compared to 136 healthy donors. Statistical analysis was performed by using X2 test, Fischer's Exact Test, and analysis for repeated measurements. The group of HIV+ patients had an unexpected lower frequency of FasLnt169 polymorphism (delT allele) than healthy controls (p=0.039). We then observed no significant differences in the immune reconstitution, in terms of CD4+ T cell increase, when the influence of single alleles of the gene Fas or FasL was considered. However, the combination of some polymorphisms of Fas or FasL significantly influenced CD4+ T cell production and viral load decrease, showing that these genes can play a role in the immunoreconstitution triggered by antiretroviral therapy.

Keywords

AIDSHIVHAARTApoptosisCD95/Apo-1/Fas gene polymorphismCD178/CD95L/FasL gene polymorphism

Abbreviations

NRTI

nucleosidic reverse transcriptase inhibitors

NNRTI

non-nucleosidic reverse transcriptase inhibitors

PI

protease inhibitors

HIV

human immunodeficiency virus

Copyright information

© Springer-Verlag 2005