Immunogenetics

, Volume 54, Issue 4, pp 282–285

Association study of the NRAMP1 gene promoter polymorphism and early-onset type 1 diabetes

  • Wafaa M. Bassuny
  • Kenji Ihara
  • Nobuo Matsuura
  • Saifuddin Ahmed
  • Hitoshi Kohno
  • Ryuichi Kuromaru
  • Kenichi Miyako
  • Toshiro Hara
Brief Communication

DOI: 10.1007/s00251-002-0459-3

Cite this article as:
Bassuny, W.M., Ihara, K., Matsuura, N. et al. Immunogenetics (2002) 54: 282. doi:10.1007/s00251-002-0459-3

Abstract.

Natural resistance-associated macrophage protein 1 (NRAMP1) has an important role in regulating macrophage functions that affect innate resistance as well as immune responses. We analyzed the microsatellite polymorphism in the promoter region of the human NRAMP1 gene in 206 type 1 diabetes patients and 200 normal children to determine whether this polymorphism might be associated with type 1 diabetes in the Japanese population. The frequency of allele 2 (180 bp) of the promoter microsatellite polymorphism of the NRAMP1 gene was slightly lower in the early-onset population (2–10 years of age) of type 1 diabetes patients than in controls, although the difference did not reach statistical significance. The association study of the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene, located near the NRAMP1 gene, and type 1 diabetes showed that the CTLA-4 gene significantly contributed to the development of type 1 diabetes, whereas NRAMP1 had an additional effect on the onset of type 1 diabetes in the young population.

NRAMP1 CTLA-4 Polymorphism Type 1 diabetes

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Wafaa M. Bassuny
    • 1
  • Kenji Ihara
    • 1
  • Nobuo Matsuura
    • 2
  • Saifuddin Ahmed
    • 1
  • Hitoshi Kohno
    • 3
  • Ryuichi Kuromaru
    • 1
  • Kenichi Miyako
    • 3
  • Toshiro Hara
    • 1
  1. 1.Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  2. 2.Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan
  3. 3.Department of Endocrinology and Metabolism, Fukuoka Children's Hospital, Fukuoka, Japan
  4. 4.Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3–1-1 Maidashi, Higashi-Ku, Fukuoka 812–8582, Japan