Immunogenetics

, Volume 53, Issue 10, pp 989–991

MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients

Authors

  • Antonio Lopez-Vazquez
    • Department of Immunology, Hospital Central de Asturias, C/ Celestino Villamil, 33.006 Oviedo, Spain
  • Luis Rodrigo
    • Department of Gastroenterology, Hospital Central de Asturias, Oviedo, Spain
  • Dolores Fuentes
    • Department of Gastroenterology, Hospital Central de Asturias, Oviedo, Spain
  • Sabino Riestra
    • Gastroenterology Section, Hospital Valle del Nalón, Sama de Langreo, Asturias, Spain
  • Carlos Bousoño
    • Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain
  • Sonia Garcia-Fernandez
    • Department of Immunology, Hospital Central de Asturias, C/ Celestino Villamil, 33.006 Oviedo, Spain
  • Jesús Martinez-Borra
    • Department of Immunology, Hospital Central de Asturias, C/ Celestino Villamil, 33.006 Oviedo, Spain
  • Segundo Gonzalez
    • Functional Biology Department, University of Oviedo, Spain
  • Carlos Lopez-Larrea
    • Department of Immunology, Hospital Central de Asturias, C/ Celestino Villamil, 33.006 Oviedo, Spain
Brief Communication

DOI: 10.1007/s00251-001-0413-9

Cite this article as:
Lopez-Vazquez, A., Rodrigo, L., Fuentes, D. et al. Immunogenetics (2002) 53: 989. doi:10.1007/s00251-001-0413-9

Abstract.

We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA transmembrane alleles in the two clinical forms of the disease. For this reason, these 38 DQ2-negative patients were subdivided into two groups: 18 typical CD patients and 20 atypical CD patients. No differences were found in the distribution of the DRB4 allele between DQ2-negative patients and controls. The HLA-DQ8 heterodimer (DQA1*03xx/DQB1*0302) was increased in CD patients (29%) compared with controls (10%), but no statistical differences were found. No differences were observed in the frequency of these alleles between either group of CD DQ2-negative patients. MICA-A5.1 was increased in atypical CD patients when compared with the typical forms of disease (Pc=0.03) and with healthy controls (Pc=0.002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD.

Celiac disease DQ2-negative HLA-DQ alleles MICA alleles

Copyright information

© Springer-Verlag 2002