Immunogenetics

, Volume 53, Issue 10, pp 989–991

MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients

  • Antonio Lopez-Vazquez
  • Luis Rodrigo
  • Dolores Fuentes
  • Sabino Riestra
  • Carlos Bousoño
  • Sonia Garcia-Fernandez
  • Jesús Martinez-Borra
  • Segundo Gonzalez
  • Carlos Lopez-Larrea
Brief Communication

DOI: 10.1007/s00251-001-0413-9

Cite this article as:
Lopez-Vazquez, A., Rodrigo, L., Fuentes, D. et al. Immunogenetics (2002) 53: 989. doi:10.1007/s00251-001-0413-9

Abstract.

We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA transmembrane alleles in the two clinical forms of the disease. For this reason, these 38 DQ2-negative patients were subdivided into two groups: 18 typical CD patients and 20 atypical CD patients. No differences were found in the distribution of the DRB4 allele between DQ2-negative patients and controls. The HLA-DQ8 heterodimer (DQA1*03xx/DQB1*0302) was increased in CD patients (29%) compared with controls (10%), but no statistical differences were found. No differences were observed in the frequency of these alleles between either group of CD DQ2-negative patients. MICA-A5.1 was increased in atypical CD patients when compared with the typical forms of disease (Pc=0.03) and with healthy controls (Pc=0.002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD.

Celiac disease DQ2-negative HLA-DQ alleles MICA alleles

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Antonio Lopez-Vazquez
    • 1
  • Luis Rodrigo
    • 2
  • Dolores Fuentes
    • 2
  • Sabino Riestra
    • 4
  • Carlos Bousoño
    • 3
  • Sonia Garcia-Fernandez
    • 1
  • Jesús Martinez-Borra
    • 1
  • Segundo Gonzalez
    • 5
  • Carlos Lopez-Larrea
    • 1
  1. 1.Department of Immunology, Hospital Central de Asturias, C/ Celestino Villamil, 33.006 Oviedo, Spain
  2. 2.Department of Gastroenterology, Hospital Central de Asturias, Oviedo, Spain
  3. 3.Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain
  4. 4.Gastroenterology Section, Hospital Valle del Nalón, Sama de Langreo, Asturias, Spain
  5. 5.Functional Biology Department, University of Oviedo, Spain