European Biophysics Journal

, Volume 40, Issue 6, pp 747–759

Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules

  • Jiří Pokorný
  • Clarbruno Vedruccio
  • Michal Cifra
  • Ondřej Kučera
Original Paper

DOI: 10.1007/s00249-011-0688-1

Cite this article as:
Pokorný, J., Vedruccio, C., Cifra, M. et al. Eur Biophys J (2011) 40: 747. doi:10.1007/s00249-011-0688-1

Abstract

This paper describes a proposed biophysical mechanism of a novel diagnostic method for cancer detection developed recently by Vedruccio. The diagnostic method is based on frequency selective absorption of electromagnetic waves by malignant tumors. Cancer is connected with mitochondrial malfunction (the Warburg effect) suggesting disrupted physical mechanisms. In addition to decreased energy conversion and nonutilized energy efflux, mitochondrial malfunction is accompanied by other negative effects in the cell. Diminished proton space charge layer and the static electric field around the outer membrane result in a lowered ordering level of cellular water and increased damping of microtubule-based cellular elastoelectrical vibration states. These changes manifest themselves in a dip in the amplitude of the signal with the fundamental frequency of the nonlinear microwave oscillator—the core of the diagnostic device—when coupled to the investigated cancerous tissue via the near-field. The dip is not present in the case of healthy tissue.

Keywords

Cancer diagnosticsBioscanner® TRIMprob™Physical processes in cancerBiological electromagnetic fieldWater ordering in cellsNonlinear resonance interaction (NLRI)

Copyright information

© European Biophysical Societies' Association 2011

Authors and Affiliations

  • Jiří Pokorný
    • 1
  • Clarbruno Vedruccio
    • 2
  • Michal Cifra
    • 1
  • Ondřej Kučera
    • 1
    • 3
  1. 1.Institute of Photonics and ElectronicsAcademy of Sciences of the Czech RepublicPrague 8Czech Republic
  2. 2.COMSUBIN, Research OfficeItalian NavyLa SpeziaItaly
  3. 3.Faculty of Electrical EngineeringCzech Technical University in PraguePragueCzech Republic