, Volume 37, Issue 8, pp 1361-1366,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 20 May 2008

Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories

Abstract

We analyze the motion of colloids propelled by a comet-like tail of polymerizing actin filaments. The curvature of the particle trajectories deviates strongly from a Gaussian distribution, implying that the underlying microscopic processes are fluctuating in a non-independent manner. Trajectories for beads of different size all showed the same non-Gaussian behavior, while the mean curvature decreased weakly with size. A stochastic simulation that includes nucleation, force-dependent dissociation, growth, and capping of filaments, shows that the non-Gaussian curvature distribution can be explained by a positive feedback mechanism in which attached chains under higher tension are more likely to snap.

S. Schmidt and J. van der Gucht contributed equally to this paper.