European Biophysics Journal

, Volume 38, Issue 3, pp 293–303

The mechano-gated K2P channel TREK-1

Authors

  • Alexandra Dedman
    • Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097Université de Nice-Sophia Antipolis
  • Reza Sharif-Naeini
    • Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097Université de Nice-Sophia Antipolis
  • Joost H. A. Folgering
    • Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097Université de Nice-Sophia Antipolis
  • Fabrice Duprat
    • Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097Université de Nice-Sophia Antipolis
  • Amanda Patel
    • Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097Université de Nice-Sophia Antipolis
    • Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097Université de Nice-Sophia Antipolis
Review

DOI: 10.1007/s00249-008-0318-8

Cite this article as:
Dedman, A., Sharif-Naeini, R., Folgering, J.H.A. et al. Eur Biophys J (2009) 38: 293. doi:10.1007/s00249-008-0318-8

Abstract

The versatility of neuronal electrical activity is largely conditioned by the expression of different structural and functional classes of K+ channels. More than 80 genes encoding the main K+ channel alpha subunits have been identified in the human genome. Alternative splicing, heteromultimeric assembly, post-translational modification and interaction with auxiliary regulatory subunits further increase the molecular and functional diversity of K+ channels. Mammalian two-pore domain K+ channels (K2P) make up one class of K+ channels along with the inward rectifiers and the voltage- and/or calcium-dependent K+ channels. Each K2P channel subunit is made up of four transmembrane segments and two pore-forming (P) domains, which are arranged in tandem and function as either homo- or heterodimeric channels. This novel structural arrangement is associated with unusual gating properties including “background” or “leak” K+ channel activity, in which the channels show constitutive activity at rest. In this review article, we will focus on the lipid-sensitive mechano-gated K2P channel TREK-1 and will emphasize on the polymodal function of this “unconventional” K+ channel.

Keywords

Ion channels Stretch Mechanotransduction Potassium Pharmacology Physiology

Copyright information

© EBSA 2008