European Biophysics Journal

, Volume 37, Issue 3, pp 323–332

The role of exosomes in the processing of proteins associated with neurodegenerative diseases

Authors

  • Laura J. Vella
    • Department of Biochemistry and Molecular BiologyUniversity of Melbourne
    • Bio21 Molecular Science and Biotechnology InstituteUniversity of Melbourne
    • Department of PathologyUniversity of Melbourne
  • Robyn A. Sharples
    • Department of Biochemistry and Molecular BiologyUniversity of Melbourne
    • Bio21 Molecular Science and Biotechnology InstituteUniversity of Melbourne
  • Rebecca M. Nisbet
    • Department of Biochemistry and Molecular BiologyUniversity of Melbourne
    • Bio21 Molecular Science and Biotechnology InstituteUniversity of Melbourne
    • Department of PathologyUniversity of Melbourne
  • Roberto Cappai
    • Bio21 Molecular Science and Biotechnology InstituteUniversity of Melbourne
    • Department of PathologyUniversity of Melbourne
    • Mental Health Research Institute of Victoria
    • Department of Biochemistry and Molecular BiologyUniversity of Melbourne
    • Bio21 Molecular Science and Biotechnology InstituteUniversity of Melbourne
    • Department of PathologyUniversity of Melbourne
    • Mental Health Research Institute of Victoria
Review

DOI: 10.1007/s00249-007-0246-z

Cite this article as:
Vella, L.J., Sharples, R.A., Nisbet, R.M. et al. Eur Biophys J (2008) 37: 323. doi:10.1007/s00249-007-0246-z

Abstract

Exosomes are small membranous vesicles secreted by a number of cell types and can be isolated from conditioned cell media or bodily fluids such as urine and plasma. Exosome biogenesis involves the inward budding of multivesicular bodies (MVB) to form intraluminal vesicles (ILV). When fused with the plasma membrane, the MVB releases the vesicles into the extracellular environment as exosomes. Proposed functions of these vesicles include roles in cell–cell signalling, removal of unwanted proteins, and the transfer of pathogens between cells, such as HIV-1. Another such pathogen which exploits this pathway is the prion, the infectious particle responsible for the transmissible neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD) of humans or bovine spongiform encephalopathy (BSE) of cattle. Interestingly, this work is mirrored by studies on another protein involved in neurodegenerative disease, the amyloid precursor protein (APP) which is associated with Alzheimer’s disease (AD). Recent work has found APP proteolytic fragments in association with exosomes, suggesting a common pathway previously unknown for proteins associated with neurodegenerative diseases. This review will be discussing the current literature regarding the role of exosomes in secretion of the proteins, PrP and APP, and the subsequent implications for neurodegenerative disease.

Keywords

Prion proteinPrPCPrPScTransmissible spongiform encephalopathyAmyloid precursor proteinAlzheimer’s diseaseExosomes

Copyright information

© EBSA 2007