Implicit solvent simulation models for biomembranes
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- Brannigan, G., Lin, L.CL. & Brown, F.L.H. Eur Biophys J (2006) 35: 104. doi:10.1007/s00249-005-0013-y
Fully atomic simulation strategies are infeasible for the study of many processes of interest to membrane biology, biophysics and biochemistry. We review various coarse-grained simulation methodologies with special emphasis on methods and models that do not require the explicit simulation of water. Examples from our own research demonstrate that such models have potential for simulating a variety of biologically relevant phenomena at the membrane surface.