Pediatric Radiology

, Volume 43, Issue 9, pp 1063–1073

Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS)

Authors

    • Department of Radiology, The Children’s Hospital of Philadelphia, Perelman School of MedicineUniversity of Pennsylvania
    • Contrast Enhanced Ultrasound (CEUS) Task Force of the Society for Pediatric Radiology (SPR)
    • International Contrast Ultrasound Society (ICUS)
  • Frederica Papadopoulou
    • Department of RadiologyUniversity of Ioannina
    • Department of RadiologyUniversity of Ioannina
  • Aikaterini Ntoulia
    • Department of Radiology, The Children’s Hospital of Philadelphia, Perelman School of MedicineUniversity of Pennsylvania
    • Department of RadiologyUniversity of Ioannina
  • Dorothy I. Bulas
    • Division of Diagnostic Imaging and RadiologyChildren’s National Medical Center
    • Contrast Enhanced Ultrasound (CEUS) Task Force of the Society for Pediatric Radiology (SPR)
  • Brian D. Coley
    • Department of Pediatric RadiologyCincinnati Children’s Hospital Medical Center
    • Contrast Enhanced Ultrasound (CEUS) Task Force of the Society for Pediatric Radiology (SPR)
  • Lynn A. Fordham
    • Division of Pediatric Imaging, Department of Radiology, School of MedicineUniversity of North Carolina Chapel Hill
    • Contrast Enhanced Ultrasound (CEUS) Task Force of the Society for Pediatric Radiology (SPR)
  • Harriet J. Paltiel
    • Department of Radiology, Boston Children’s HopsitalHarvard University
    • Contrast Enhanced Ultrasound (CEUS) Task Force of the Society for Pediatric Radiology (SPR)
    • International Contrast Ultrasound Society (ICUS)
  • Beth McCarville
    • Division of Diagnostic Imaging, Department of Radiological SciencesSt. Jude Children’s Research Hospital
    • Contrast Enhanced Ultrasound (CEUS) Task Force of the Society for Pediatric Radiology (SPR)
  • Frank M. Volberg
    • Division of Pediatric Radiology, Department of RadiologyGeorgetown University
    • Contrast Enhanced Ultrasound (CEUS) Task Force of the Society for Pediatric Radiology (SPR)
  • David O. Cosgrove
    • Imperial College School of Medicine
    • International Contrast Ultrasound Society (ICUS)
  • Barry B. Goldberg
    • Department of RadiologyThomas Jefferson University Hospital
    • International Contrast Ultrasound Society (ICUS)
  • Stephanie R. Wilson
    • Department of Diagnostic Imaging and Department of MedicineDivision of Gastroenterology
    • International Contrast Ultrasound Society (ICUS)
  • Steven B. Feinstein
    • Section of CardiologyRush University Medical Center
    • International Contrast Ultrasound Society (ICUS)
Review

DOI: 10.1007/s00247-013-2746-6

Cite this article as:
Darge, K., Papadopoulou, F., Ntoulia, A. et al. Pediatr Radiol (2013) 43: 1063. doi:10.1007/s00247-013-2746-6

Abstract

The practice of contrast-enhanced ultrasound in children is in the setting of off-label use or research. The widespread practice of pediatric contrast-enhanced US is primarily in Europe. There is ongoing effort by the Society for Pediatric Radiology (SPR) and International Contrast Ultrasound Society (ICUS) to push for pediatric contrast-enhanced US in the United States. With this in mind, the main objective of this review is to describe the status of US contrast agent safety in non-cardiac applications in children. The five published studies using pediatric intravenous contrast-enhanced US comprise 110 children. There is no mention of adverse events in these studies. From a European survey 948 children can be added. In that survey six minor adverse events were reported in five children. The intravesical administration of US contrast agents for diagnosis of vesicoureteric reflux entails the use of a bladder catheter. Fifteen studies encompassing 2,951 children have evaluated the safety of intravesical US contrast agents in children. A European survey adds 4,131 children to this group. No adverse events could be attributed to the contrast agent. They were most likely related to the bladder catheterization. The existing data on US contrast agent safety in children are encouraging in promoting the widespread use of contrast-enhanced US.

Keywords

ChildrenUltrasound contrast agentAdverse eventContrast-enhanced ultrasound

Copyright information

© Springer-Verlag Berlin Heidelberg 2013