Pediatric Radiology

, Volume 43, Issue 9, pp 1182–1189

Clinical and MRI features of neurological complications after influenza A (H1N1) infection in critically ill children

Original Article

DOI: 10.1007/s00247-013-2682-5

Cite this article as:
Zeng, H., Quinet, S., Huang, W. et al. Pediatr Radiol (2013) 43: 1182. doi:10.1007/s00247-013-2682-5



Influenza A (H1N1) can cause severe neurological complications.


The purpose of this study was to analyze clinical and MRI features of neurological complications after H1N1 infection in critically ill children.

Materials and methods

We retrospectively analyzed clinical and neuroimaging findings in 17 children who were hospitalized in an intensive care unit with severe neurological complications after H1N1 infection in South China between September 2009 and December 2011. All children underwent pre- and post-contrast-enhanced brain MRI. Postmortem studies were performed in two children.


Six children died, five because of acute necrotizing encephalopathy (ANE) and one because of intracranial fungal infection. Eleven recovered; their manifestations of H1N1 were meningitis (3), encephalitis (1) and influenza encephalopathy (7). MRI features of ANE included multiple symmetrical brain lesions demonstrating prolonged T1 and T2 signal in the thalami, internal capsule, lenticular nucleus and pontine tegmentum. Postmortem MRI in two children with acute necrotizing encephalopathy showed diffuse prolonged T1 and T2 signal in the bilateral thalami, brainstem deformation and tonsillar herniation.


Fatal neurological complications in children after H1N1 infection include ANE and opportunistic fungal infection. MRI is essential for identification of neurological complications and for clinical evaluation.


Neurological complicationsAcute necrotizing encephalopathyInfluenza A (H1N1)Magnetic resonance imagingChildhood

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of RadiologyShenzhen Children’s HospitalGuangdongChina
  2. 2.Shenzhen CityChina
  3. 3.Department of RadiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  4. 4.BrookfieldUSA
  5. 5.Department of Respiratory MedicineShenzhen Children’s HospitalGuangdongChina
  6. 6.Department of PathologyShenzhen Children’s HospitalGuangdongChina
  7. 7.Pediatric Intensive Care UnitShenzhen Children’s HospitalGuangdongChina