Pediatric Radiology

, Volume 43, Issue 5, pp 545–551

Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children

  • Sylviane Hanquinet
  • Anne‐Laure Rougemont
  • Delphine Courvoisier
  • Laura Rubbia-Brandt
  • Valérie Mclin
  • Michela Tempia
  • Mehrak Anooshiravani
Original Article

DOI: 10.1007/s00247-012-2595-8

Cite this article as:
Hanquinet, S., Rougemont, A., Courvoisier, D. et al. Pediatr Radiol (2013) 43: 545. doi:10.1007/s00247-012-2595-8

Abstract

Background

Acoustic radiation force impulse (ARFI) imaging) is correlated with histopathological findings using METAVIR and semiquantitative scoring system (SSS) criteria for liver fibrosis.

Objective

To compare acoustic radiation force impulse imaging with biopsy results in the evaluation of liver fibrosis in children.

Materials and methods

Children with chronic liver disease and healthy children underwent acoustic radiation force impulse imaging liver measurements. ARFI gives a shear-wave velocity corresponding to tissue elasticity. In 39 children with liver disease, the values obtained were correlated with biopsy results. Receiver-operating characteristic (ROC) curves were used to determine the reliability of ARFI in estimating liver fibrosis in children.

Results

ARFI mean value was 1.12 in the healthy group and 1.99 in children with chronic liver disease. ROC curves show that an ARFI cutoff of 1.34 m/s is predictive of both METAVIR and SSS scores with a sensitivity of SSS > 2:0.85; METAVIR > F0:0.82. A cutoff of 2 m/s yielded a sensitivity of 100% to detect SSS > 4 or METAVIR > F2.

Conclusion

Acoustic radiation force impulse imaging is a reliable, noninvasive and rapid method to estimate moderate to severe liver fibrosis in children. It might prove useful to clinicians for fibrosis monitoring in children with liver disease and postpone the time of liver biopsy.

Keywords

Liver fibrosisARFI elastographyLiver diseaseChild

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Sylviane Hanquinet
    • 1
    • 6
  • Anne‐Laure Rougemont
    • 2
  • Delphine Courvoisier
    • 3
    • 4
  • Laura Rubbia-Brandt
    • 2
  • Valérie Mclin
    • 5
  • Michela Tempia
    • 5
  • Mehrak Anooshiravani
    • 1
  1. 1.Department of Pediatric RadiologyUniversity Hospitals GenevaGenevaSwitzerland
  2. 2.Division of Clinical PathologyUniversity Hospitals GenevaGenevaSwitzerland
  3. 3.Division of Clinical EpidemiologyUniversity of GenevaGenevaSwitzerland
  4. 4.Department of PsychologyHarvard UniversityCambridgeUSA
  5. 5.Department of Pediatric GastroenterologyUniversity Hospitals GenevaGenevaSwitzerland
  6. 6.Unité de RadiopédiatrieHôpital Universitaire des EnfantsGenève 14Switzerland