Pediatric Radiology

, Volume 43, Issue 1, pp 86–92

Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease—added value of low-dose CT

  • Anat Ilivitzki
  • Lea Radan
  • Miriam Ben-Arush
  • Ora Israel
  • Ayelet Ben-Barak
Original Article

DOI: 10.1007/s00247-012-2517-9

Cite this article as:
Ilivitzki, A., Radan, L., Ben-Arush, M. et al. Pediatr Radiol (2013) 43: 86. doi:10.1007/s00247-012-2517-9

Abstract

Background

Interim 18F-FDG PET helps predict outcome and tailor treatment in adults with Hodgkin disease (HD).

Objective

The purpose of this study was to assess predictive values of interim 18F-FDG PET/CT in children with HD and to define the potential added value to interim PET of low-dose CT.

Materials and methods

Children were prospectively enrolled August 2002–April 2007. PET/low-dose CT was performed at staging, after 2 cycles, at the end of treatment and during follow-up (mean 45 months). Treatment was unchanged regardless of interim results. PET and low-dose CT were read independently.

Results

Of 34 enrolled children (ages 3–17 years), 27 achieved complete response, 4 had progressive disease and 3 had relapse. Interim PET alone had positive and negative predictive values of 67% and 89%, respectively. Interim low-dose CT alone had positive and negative predictive values of 35% and 100%, respectively. Interim PET/CT had positive and negative predictive values of 75% and 96%, respectively.

Conclusions

Early interim PET/CT was a good predictor of outcome. Integrated PET and low-dose CT improved the predictive value in children with HD.

Keywords

Hodgkin diseaseInterim PET/CTPediatric malignancyALARA

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Anat Ilivitzki
    • 1
    • 4
  • Lea Radan
    • 2
  • Miriam Ben-Arush
    • 3
  • Ora Israel
    • 2
  • Ayelet Ben-Barak
    • 3
  1. 1.Department of Diagnostic ImagingRambam Health Care CampusHaifaIsrael
  2. 2.Department of Nuclear MedicineRambam Health Care CampusHaifaIsrael
  3. 3.Department of Pediatric OncologyRambam Health Care CampusHaifaIsrael
  4. 4.Department of Pediatric RadiologyRambam Health Care CampusHaifaIsrael