Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease—added value of low-dose CT
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Interim 18F-FDG PET helps predict outcome and tailor treatment in adults with Hodgkin disease (HD).
The purpose of this study was to assess predictive values of interim 18F-FDG PET/CT in children with HD and to define the potential added value to interim PET of low-dose CT.
Materials and methods
Children were prospectively enrolled August 2002–April 2007. PET/low-dose CT was performed at staging, after 2 cycles, at the end of treatment and during follow-up (mean 45 months). Treatment was unchanged regardless of interim results. PET and low-dose CT were read independently.
Of 34 enrolled children (ages 3–17 years), 27 achieved complete response, 4 had progressive disease and 3 had relapse. Interim PET alone had positive and negative predictive values of 67% and 89%, respectively. Interim low-dose CT alone had positive and negative predictive values of 35% and 100%, respectively. Interim PET/CT had positive and negative predictive values of 75% and 96%, respectively.
Early interim PET/CT was a good predictor of outcome. Integrated PET and low-dose CT improved the predictive value in children with HD.
- Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease—added value of low-dose CT
Volume 43, Issue 1 , pp 86-92
- Cover Date
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- Hodgkin disease
- Interim PET/CT
- Pediatric malignancy
- Industry Sectors
- Author Affiliations
- 1. Department of Diagnostic Imaging, Rambam Health Care Campus, Haifa, Israel
- 4. Department of Pediatric Radiology, Rambam Health Care Campus, 32 Hatzalbanim str, Haifa, Israel
- 2. Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel
- 3. Department of Pediatric Oncology, Rambam Health Care Campus, Haifa, Israel