Pediatric Radiology

, Volume 43, Issue 1, pp 80–85

Effect of antenatal growth on brain white matter maturation in preterm infants at term using tract-based spatial statistics

  • Virva Lepomäki
  • Jaakko Matomäki
  • Helena Lapinleimu
  • Liisa Lehtonen
  • Leena Haataja
  • Markku Komu
  • Riitta Parkkola
  • The PIPARI Study Group
Original Article

DOI: 10.1007/s00247-012-2509-9

Cite this article as:
Lepomäki, V., Matomäki, J., Lapinleimu, H. et al. Pediatr Radiol (2013) 43: 80. doi:10.1007/s00247-012-2509-9

Abstract

Background

White matter maturation of infants can be studied using diffusion tensor imaging (DTI). DTI of the white matter of the infant brain provides the best available clinical measures of brain tissue organisation and integrity.

Objective

The purpose of this study was to compare white matter maturation between preterm infants born small for gestational age (SGA) and preterms with weight appropriate for gestational age (AGA) at birth.

Materials and methods

A total of 36 preterm infants were enrolled in the study (SGA, n = 9). A rater-independent method called tract-based spatial statistics (TBSS) was used to assess white matter maturation.

Results

When measured by TBSS, the AGA infants showed higher fractional anisotrophy values in several white matter tracts than the SGA infants. Areas with significant differences included anterior thalamic radiation, corticospinal tract, forceps major and minor, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, and superior longitudinal fasciculus (temporal part). No significant difference was found for mean diffusivity.

Conclusion

As an objective and user-independent method, TBSS confirmed that preterm infants with impaired antenatal growth have impaired white matter maturation compared to preterm infants with normal antenatal growth. The differences were mainly detected in radiations that are myelinated first.

Keywords

Diffusion tensor imagingTract-based spatial statisticsBrainPreterm infant

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Virva Lepomäki
    • 1
    • 2
  • Jaakko Matomäki
    • 3
  • Helena Lapinleimu
    • 3
  • Liisa Lehtonen
    • 3
  • Leena Haataja
    • 4
  • Markku Komu
    • 1
  • Riitta Parkkola
    • 1
    • 2
    • 5
  • The PIPARI Study Group
  1. 1.Medical Imaging Centre of Southwest FinlandTurku University HospitalTurkuFinland
  2. 2.Turku PET-CentreTurku University HospitalTurkuFinland
  3. 3.Department of PediatricsTurku University Hospital and University of TurkuTurkuFinland
  4. 4.Department of Pediatric NeurologyTurku University Hospital and University of TurkuTurkuFinland
  5. 5.Department of Diagnostic RadiologyUniversity of TurkuTurkuFinland