, Volume 42, Issue 12, pp 1538-1539
Date: 18 Nov 2012


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Abnormalities of vascular structure and function in children with Perthes disease

Perry DC, Green DJ, Bruce CE et al

Pediatrics (2012)130:e126–131

The mechanism by which avascular necrosis of the femoral head develops is unknown, but it is hypothesized that there is diminished blood supply via the lateral ascending vessel to the femoral head epiphysis. Researchers have suggested that abnormalities in vascular structure and function may be the etiology, including the possibility of endothelial dysfunction. Endothelial dysfunction may precipitate inflammation, thrombosis, vasoconstriction, and plaque formation. Adults who had Perthes disease as children have been shown to have a greater risk of premature cardiovascular disease, adding support to this theory. This case-controlled study included 149 patients age 5–16 years with Perthes disease along with 146 matched controls. Endothelial function was evaluated by using a well-established protocol of sonographically measuring the degree of bra ...