Pediatric Radiology

, Volume 41, Issue 3, pp 341–349

Focal nodular hyperplasia in children, adolescents, and young adults

  • Alexander J. Towbin
  • Guangju G. Luo
  • Hong Yin
  • Jun Q. Mo
Original Article

DOI: 10.1007/s00247-010-1839-8

Cite this article as:
Towbin, A.J., Luo, G.G., Yin, H. et al. Pediatr Radiol (2011) 41: 341. doi:10.1007/s00247-010-1839-8

Abstract

Background

Focal nodular hyperplasia (FNH) is a benign hepatic tumor that is rare in children. In order to understand whether there are differences in the etiology or appearance of FNH in children, we analyzed the clinical information and imaging of pathologically proven cases.

Materials and methods

A pathology database was used to identify all cases of FNH diagnosed at our institution. Each patient’s imaging was evaluated for the characteristics of FNH lesions. Clinical information was obtained on each patient.

Results

Thirteen patients with FNH were identified (7 male/6 female, mean age 14.3 years, range 1–27 years). Seven patients (5 male/2 female) had a remote history of childhood malignancy. The time interval between the diagnoses of malignancy and FNH ranged from 9 to 27 years (mean 14.4 years). On imaging, all seven cancer survivors had multiple liver lesions. In the remaining six patients (2 male/4 female), there was no history of malignancy and all but one of these patients had a solitary FNH.

Conclusion

Half of the patients with FNH in this study were long-term cancer survivors and each of these patients had multiple masses. Recognizing the features of FNH will aid in diagnosis and appropriate management.

Keywords

FNHHepatic tumorLiver tumorChildrenAdolescentsFocal nodular hyperplasia

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Alexander J. Towbin
    • 1
  • Guangju G. Luo
    • 2
  • Hong Yin
    • 2
  • Jun Q. Mo
    • 2
  1. 1.Department of RadiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  2. 2.Department of PathologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA