Pediatric Radiology

, Volume 35, Issue 10, pp 998–1005

Chemical shift imaging and localised magnetic resonance spectroscopy in full-term asphyxiated neonates

  • Olivier Brissaud
  • Jean-François Chateil
  • Martine Bordessoules
  • Muriel Brun
Original Article

DOI: 10.1007/s00247-005-1524-5

Cite this article as:
Brissaud, O., Chateil, JF., Bordessoules, M. et al. Pediatr Radiol (2005) 35: 998. doi:10.1007/s00247-005-1524-5
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Abstract

Background: Diagnosis of brain lesions after birth anoxia-ischemia is essential for appropriate management. Clinical evaluation is not sufficient. MRI has been proven to provide useful information. Objective: To compare abnormalities observed with MRI, including diffusion-weighted imaging (DWI), localised magnetic resonance spectroscopy (MRS) and chemical shift imaging (CSI) and correlate these findings with the clinical outcome. Materials and methods: Fourteen full-term neonates with birth asphyxia were studied. MRI, MRS and CSI were performed within the first 4 days of life. Results: Lesions observed with DWI were correlated with outcome, but the apparent diffusion coefficient (ADC) did improve diagnostic confidence. The mean value of Lac/Cr for the neonates with a favourable outcome was statically lower than for those who died (0.22 vs 1.04; P = 0.01). The same results were observed for the Lac/NAA ratio (0.21 vs 1.23; P = 0.01). Data obtained with localised MRS and CSI were correlated for the ratio N-acetyl-aspartate/choline, but not for the other metabolites. No correlation was found between the ADC values and the metabolite ratios. Conclusions: Combination of these techniques could be helpful in our understanding of the physiopathological events occurring in neonates with asphyxia.

Keywords

Brain Asphyxia MRI MRS DWI Neonates 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Olivier Brissaud
    • 1
  • Jean-François Chateil
    • 2
  • Martine Bordessoules
    • 2
  • Muriel Brun
    • 2
  1. 1.Paediatric Intensive Care UnitChildren’s HospitalBordeauxFrance
  2. 2.Radiology UnitChildren’s HospitalBordeauxFrance

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