Pediatric Radiology

, Volume 32, Issue 6, pp 413–417

Magnetic resonance cholangiopancreatography in primary sclerosing cholangitis in children

Authors

  • Calogero Ferrara
    • Department of Radiology, MR Centre F. Angelini, University of Ancona, Ospedale Torrette, Via Conca, 60020 Torrette, Ancona
  • Gianluca Valeri
    • Department of Radiology, MR Centre F. Angelini, University of Ancona, Ospedale Torrette, Via Conca, 60020 Torrette, Ancona
  • Luca Salvolini
    • Department of Radiology, MR Centre F. Angelini, University of Ancona, Ospedale Torrette, Via Conca, 60020 Torrette, Ancona
  • Andrea Giovagnoni
    • Department of Radiology, University of Modena
Original Article

DOI: 10.1007/s00247-001-0617-z

Cite this article as:
Ferrara, C., Valeri, G., Salvolini, L. et al. Ped Radiol (2002) 32: 413. doi:10.1007/s00247-001-0617-z

Abstract

Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown aetiology. Diagnosis is based on clinical and laboratory data in conjunction with imaging of the biliary tree using endoscopic retrograde cholangiopancreatography (ERCP). Objective: To evaluate the clinical usefulness of MR cholangiopancreatography (MRCP) in the diagnosis of PSC in children. Materials and methods: Twenty-one children with clinical and laboratory suspicion of PSC were enrolled. MRCP was performed using a superconductive system with a phased-array coil. Rapid acquisition with relaxation enhancement (RARE) T2-weighted and half-Fourier single-shot turbo-spin-echo (HASTE) sequences were used. The distribution and extent of biliary tree changes were evaluated and classified according to Majoie's classification. A comparison between MRCP and ERCP was performed blind in all cases to evaluate the usefulness of MRI. Results: In 13 cases (62%), MRCP showed abnormalities of the biliary tree which were considered positive for PSC, while in 8 cases there were no signs of PSC. Both MRCP and ERCP correctly identified changes in 13 cases and excluded abnormalities in 5. MRCP had a sensitivity of 81%, specificity of 100%, negative predictive value of 62%, positive predictive value of 100% and an accuracy of 85%. Conclusions: MRCP can be proposed as the preliminary non-invasive imaging modality for the diagnosis of PSC in children.

MRI Cholangiography Liver Primary sclerosing cholangitis

Copyright information

© Springer-Verlag 2002