Pediatric Cardiology

, Volume 32, Issue 3, pp 290–296

Cardiomyocyte Death: Insights from Molecular and Microstructural Magnetic Resonance Imaging

Riley Symposium

DOI: 10.1007/s00246-011-9894-y

Cite this article as:
Berry, N.C. & Sosnovik, D.E. Pediatr Cardiol (2011) 32: 290. doi:10.1007/s00246-011-9894-y

Abstract

Cardiomyocytes can die via necrosis, apoptosis, and autophagy. Although the molecular signals and pathways underlying these processes have been well elucidated, the pathophysiology of cardiomyocyte death remains incompletely understood. This review describes the development and application of novel imaging techniques to detect and characterize cardiomyocyte death noninvasively in vivo. It focuses on molecular and microstructural magnetic resonance images (MRIs) and their respective abilities to image cellular events such as apoptosis, inflammation, and myofiber architecture. These in vivo imaging techniques have the potential to provide novel insights into the mechanisms of cardiomyocyte death and to help guide the development of novel cardioprotective therapies.

Keywords

ApoptosisDiffusionMolecular imagingMRIMyocardiumNecrosis

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Martinos Center for Biomedical ImagingMassachusetts General Hospital, Harvard Medical SchoolCharlestownUSA
  2. 2.Center for Molecular Imaging ResearchMassachusetts General Hospital, Harvard Medical SchoolCharlestownUSA