Pediatric Cardiology

, Volume 32, Issue 3, pp 354–359

Mechanism of Cardioprotection: What Can We Learn from Females?

  • Elizabeth Murphy
  • Claudia Lagranha
  • Anne Deschamps
  • Mark Kohr
  • Tiffany Nguyen
  • Renee Wong
  • Junhui Sun
  • Charles Steenbergen
Riley Symposium

DOI: 10.1007/s00246-010-9877-4

Cite this article as:
Murphy, E., Lagranha, C., Deschamps, A. et al. Pediatr Cardiol (2011) 32: 354. doi:10.1007/s00246-010-9877-4

Abstract

This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.

Keywords

Cardioprotection Estrogen signaling G-protein-coupled receptor Nuclear estrogen receptors 

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2011

Authors and Affiliations

  • Elizabeth Murphy
    • 1
  • Claudia Lagranha
    • 1
  • Anne Deschamps
    • 1
  • Mark Kohr
    • 1
    • 2
  • Tiffany Nguyen
    • 1
  • Renee Wong
    • 1
  • Junhui Sun
    • 1
  • Charles Steenbergen
    • 2
  1. 1.NHLBI, NIHBethesdaUSA
  2. 2.Johns Hopkins UniversityBaltimoreUSA