, Volume 32, Issue 3, pp 354-359
Date: 29 Jan 2011

Mechanism of Cardioprotection: What Can We Learn from Females?

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Abstract

This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.