Pediatric Cardiology

, Volume 29, Issue 4, pp 732–738

Preliminary Data on the Diagnostic Accuracy of Rubidium-82 Cardiac PET Perfusion Imaging for the Evaluation of Ischemia in a Pediatric Population

  • Adnan K. Chhatriwalla
  • Lourdes R. Prieto
  • Richard C. Brunken
  • Manuel D. Cerqueira
  • Adel Younoszai
  • Wael A. Jaber
Original Article

DOI: 10.1007/s00246-008-9232-1

Cite this article as:
Chhatriwalla, A.K., Prieto, L.R., Brunken, R.C. et al. Pediatr Cardiol (2008) 29: 732. doi:10.1007/s00246-008-9232-1

Abstract

Evaluation of myocardial perfusion is sometimes necessary in children with congenital heart disease or acquired coronary artery abnormalities. Limited information is available regarding the clinical utility of myocardial perfusion imaging in children. PET imaging with rubidium-82 may provide a convenient clinical means of assessing regional circulatory compromise in pediatric patients with small hearts, due to its improved spatial resolution. Clinically indicated cardiac PET studies obtained in 22 pediatric patients were reviewed by two blinded observers and assigned myocardial perfusion scores using a standard 17-segment model. PET results were correlated with coronary angiography, available in 15 cases, to determine the accuracy of PET scanning for evaluating compromise of the myocardial circulation. Reversible defects consistent with myocardial ischemia were present in 6 of 15 (40%) PET cases. The sensitivity and specificity of cardiac PET for the detection of significant coronary artery disease were 100% and 82%, respectively. The positive predictive value of cardiac PET was 67%, while the negative predictive value was 100%. Cardiac PET imaging with rubidium-82 appears promising for the noninvasive assessment of myocardial perfusion in the pediatric population. The findings from this small series suggest that prospective study in a larger patient cohort merits consideration.

Keywords

Positron emission tomographyMyocardial perfusion

Abbreviations

PET

Positron emission tomography

VSD

Ventricular septal defect

SPECT

Single photon emission computed tomography

EKG

Electrocardiogram

BMI

Body mass index

AS

Aortic stenosis

LAD

Left anterior descending artery

CX

Circumflex artery

RCA

Right coronary artery

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Adnan K. Chhatriwalla
    • 1
  • Lourdes R. Prieto
    • 2
  • Richard C. Brunken
    • 1
    • 3
  • Manuel D. Cerqueira
    • 1
    • 3
  • Adel Younoszai
    • 4
  • Wael A. Jaber
    • 1
    • 3
  1. 1.Department of Cardiovascular MedicineCleveland ClinicClevelandUSA
  2. 2.Department of Pediatric CardiologyCleveland ClinicClevelandUSA
  3. 3.Department of Nuclear MedicineCleveland ClinicClevelandUSA
  4. 4.Department of Pediatric Cardiology, Health Sciences CenterThe University of Colorado at DenverDenverUSA