Pediatric Cardiology

, Volume 29, Issue 5, pp 906–909

Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Pediatric Patients with Mid to Severe Aortic Valve Regurgitation

  • Fabian Gisler
  • Walter Knirsch
  • Paul Harpes
  • Urs Bauersfeld
Original Article

DOI: 10.1007/s00246-008-9228-x

Cite this article as:
Gisler, F., Knirsch, W., Harpes, P. et al. Pediatr Cardiol (2008) 29: 906. doi:10.1007/s00246-008-9228-x

Abstract

The long-term benefit of angiotensin-converting enzyme inhibitors in pediatric patients with aortic valve regurgitation is under consideration. Eighteen patients with mid to severe aortic valve regurgitation were retrospectively evaluated. Echocardiographic parameters (left ventricular end-diastolic diameter, shortening fraction, left ventricular posterior wall thickness, and grade of aortic valve regurgitation) were analyzed before and during therapy with angiotensin-converting enzyme inhibitors. Data are given as standard deviation scores (Z-scores) derived from body surface-adjusted normal values. Median (interquartile range) age at start of therapy was 8.4 (5.4 to 10.0) years, and total follow-up 2.3 (0.9 to 5.4) years. Left ventricular end-diastolic diameter increased from 3.6 (2.3 to 4.5) to 3.7 (2.4 to 4.8), and left ventricular posterior wall diameter decreased from 1.9 (1.1 to 3.0) to 1.1 (0.5 to 2.3). Grade of aortic valve regurgitation increased from 3.5 (2.3 to 4.0) to 4.0 (2.0 to 4.0), and shortening fraction decreased from 39% (34% to 43%) to 37% (34% to 42%). No significant effect of angiotensin-converting enzyme inhibitors on left ventricular dimensions or function was found in our population of patients with mid to severe aortic valve regurgitation. Angiotensin-converting enzyme inhibitors may not alter left ventricular overload in pediatric patients with aortic valve regurgitation.

Keywords

Aortic valve regurgitation Angiotensin-converting enzyme inhibitor Echocardiography 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Fabian Gisler
    • 1
  • Walter Knirsch
    • 1
  • Paul Harpes
    • 2
  • Urs Bauersfeld
    • 1
  1. 1.Division of Paediatric CardiologyUniversity Children’s HospitalZurichSwitzerland
  2. 2.Department of BiostatisticsUniversity ZurichZurichSwitzerland

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