Pediatric Cardiology

, Volume 24, Issue 5, pp 473–475

Three Cases of Myocarditis in Childhood Associated with Human Parvovirus (B19 Virus)

Original Article

DOI: 10.1007/s00246-002-0173-9

Cite this article as:
Munro, K., Croxson, M., Thomas, S. et al. Pediatr Cardiol (2003) 24: 473. doi:10.1007/s00246-002-0173-9

Abstract

We report three childhood cases of myocarditis associated with human parvovirus (B19 virus). All three children presented with significant cardiac decompensation, with one requiring extracorporeal membrane oxygenation support. Left ventricular function was severely impaired in all three. Myocardial biopsy confirmed histological myocarditis and was positive for B19 virus by nested polymerase chain reaction. Serum was positive for IgG B19 virus but negative for IgM in all three cases. All three children were treated with diuretics, ACE inhibitors, and immunosuppression. Prednisone and cyclosporin were continued until there was echocardiographic and histological improvement. All made a full clinical and echocardiographic recovery.

Keywords

MyocarditisChildhoodParvovirus

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • K. Munro
    • 1
  • M. C. Croxson
    • 2
  • S. Thomas
    • 2
  • N. J. Wilson
    • 1
  1. 1.Department of Paediatric CardiologyGreen Lane Hospital, Private Bag 92 189, Green Lane West, Auckland 1030New Zealand
  2. 2.Department of Virology and ImmunologyAuckland Public Hospital, Auckland 1030New Zealand