Archives of Environmental Contamination and Toxicology

, Volume 37, Issue 3, pp 408–414

Distribution of PCB Congeners, DDE, Hexachlorobenzene, and Methylsulfonyl Metabolites of PCB and DDE Among Various Fractions of Human Blood Plasma


  • K.  Norén
    •  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden
  • C.  Weistrand
    •  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden
  • F.  Karpe
    •  King Gustaf V Research Institute, Karolinska Hospital, S-171 76 Stockholm, Sweden

DOI: 10.1007/s002449900532

Cite this article as:
Norén, K., Weistrand, C. & Karpe, F. Arch. Environ. Contam. Toxicol. (1999) 37: 408. doi:10.1007/s002449900532


The concentrations of chlorinated biphenyls (CBs), 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (DDE), hexachlorobenzene (HCB), and the methylsulfonyl metabolites of CBs (MeSO2-CBs) and DDE (MeSO2-DDE) were determined in human plasma samples and in the fractions obtained by ultracentrifugation of plasma into very-low-density (VLDL), low-density (LDL), high-density (HDL) lipoprotein and lipoprotein depleted (LPDP) fractions (containing primarily albumin). The concentrations of triacylglycerols, cholesterol, phospholipids, and apolipoprotein B (apoB) were determined. The organochlorine compounds were associated with all fractions, but predominantly with the LPDP fraction. On an average 44% of CBs, 61% of MeSO2-CBs, 73% of DDE, 77% of MeSO2-DDE, and 45% of HCB were distributed in the LPDP fraction. A tendency to greater association of 3-methylsulfonyl substituted than of corresponding 4-methylsulfonyl substituted chlorobiphenyls to the LPDP fraction was noticed. Among the lipoprotein fractions, LDL was the main carrier of HCB, DDE and CBs. MeSO2-DDE was predominantly found in HDL and MeSO2-CBs were distributed equally among the LDL and HDL fractions. Calculating the concentrations of organochlorine compounds in relation to the content of apoB, the levels were about 10 times higher in VLDL than in LDL.

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© Springer-Verlag New York Inc. 1999