, Volume 62, Issue 2, pp 195-209
Date: 17 Jul 2011

Application of the Similarity Parameter (λ) to Prediction of the Joint Effects of Nonequitoxic Mixtures

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Abstract

Although environmental contaminants are usually encountered as nonequitoxic mixtures, most studies have investigated the toxicity of equitoxic mixtures. In the present study, a method for prediction of the toxicity of nonequitoxic mixtures was developed using the similarity parameter (λ). The joint effect of multiple contaminants at the median inhibition concentration in equitoxic ( \( {\text{TU}}_{\text{sum-50}}^{\text{equitoxic}} \) ) and nonequitoxic ( \( {\text{TU}}_{\text{sum-50}}^{\text{nonequitoxic}} \) ) binary, ternary, and quaternary mixtures was investigated using Vibrio fischeri. The observed results indicate that the concentration ratios of individual chemicals in the mixtures influenced the joint effects, and that λ could be employed to evaluate the relation between \( {\text{TU}}_{\text{sum-50}}^{\text{equitoxic}} \) and \( {\text{TU}}_{\text{sum-50}}^{\text{nonequitoxic}} \) . Prediction models for the joint effects of nonequitoxic ( \( {\text{TU}}_{\text{sum-50}}^{\text{nonequitoxic}} \) ) mixtures were derived from a combination of \( {\text{TU}}_{\text{sum-50}}^{\text{equitoxic}} \) and λ. The predictive capabilities of these models were validated by comparing the predicted data with the observed data for binary, ternary, and quaternary mixtures. The prediction models have promising applications in controlling environmental pollution, evaluating drug interactions, and optimizing combinations of pesticides used in agriculture.