Article

Archives of Environmental Contamination and Toxicology

, Volume 51, Issue 2, pp 287-295

Selected Haematological and Biochemical Parameters of Blood in Rats After Subchronic Administration of Vanadium and/or Magnesium in Drinking Water

  • Agnieszka ŚcibiorAffiliated withDepartment of Cell Biology, Institute of Environmental Protection, John Paul II Catholic University of Lublin Email author 
  • , Halina ZaporowskaAffiliated withDepartment of Cell Biology, Institute of Environmental Protection, John Paul II Catholic University of Lublin
  • , Jarosław OstrowskiAffiliated withVoivodship Inspectorate of Environmental Protection

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Abstract

The purpose of these studies was to evaluate the effect of selected vanadium and magnesium doses on certain haematological and biochemical blood parameters in rats. Outbred 2-month-old, albino male Wistar rats received for a period of 6 weeks, as a sole drinking liquid, the following water solutions: group II, sodium metavanadate (SMV) at a concentration of 0.125 mg V/mL; group III, magnesium sulphate (MS) at a concentration of 0.06 mg Mg/mL; and group IV, SMV-MS solution at the same concentrations. The control group received at this time deionized water to drink. It was calculated that group II ingested with drinking water about 10.7 mg V/kg b. w./24 h, group III 6 mg Mg/kg b. w./24 h, and group IV about 9 mg V and 4.5 mg Mg/kg b. w./24 h. The exposure to vanadium alone (group II) led to a statistically significant decrease in body weight gain, food and fluid intakes. Moreover, in the same group of rats a statistically significant decrease in the RBC count, Hb concentration, MCV, and MCH values was demonstrated. Additionally, a statistically significant decrease in the plasma L-ascorbic acid concentration and a significant increase in MDA concentration in blood in this group were found. Instead, after the administration of magnesium alone (group III), a statistically significant decrease in the fluid intake and in the L-ascorbic acid concentration in plasma was noted. Furthermore, in the same group of rats a statistically significant increase in Hb level and in the plasma magnesium concentration was demonstrated. Two-way analysis of variance (ANOVA) did not reveal the interactions between V and Mg.