Archives of Environmental Contamination and Toxicology

, Volume 42, Issue 3, pp 263–271

Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria

Authors

  • B. Halling-Sørensen
    • Section of Environmental Chemistry, Dept. of Analytical and Pharmaceutical Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark
  • G. Sengeløv
    • Department of Microbiology, Danish Veterinary Laboratory, Bülowsvej 27, DK-1790 Copenhagen V, Denmark
  • J. Tjørnelund
    • Section of Environmental Chemistry, Dept. of Analytical and Pharmaceutical Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark

DOI: 10.1007/s00244-001-0017-2

Cite this article as:
Halling-Sørensen, B., Sengeløv, G. & Tjørnelund, J. Arch. Environ. Contam. Toxicol. (2002) 42: 263. doi:10.1007/s00244-001-0017-2

Abstract

Tetracyclines used in veterinary therapy invariably will find their way as parent compound and degradation products to the agricultural field. Major degradation products formed due to the limited stability of parent tetracyclines (tetracycline, chlortetracycline, and oxytetracycline) in aqueous solution were theoretically identified at various environmental conditions, such as pH, presence of chelating metals, and light. Their potency was assessed on sludge bacteria, tetracycline-sensitive soil bacteria, and tetracycline-resistant strains. Several of the degradation products had potency at the same concentration level as tetracycline, chlortetracycline, and oxytetracycline on both the sludge and the tetracycline-sensitive soil bacteria. Further, both 5a,6-anhydrotetracycline and 5a,6-anhydrochlortetracycline had potency on tetracycline-resistant bacteria supporting a mode of action different from that of the parent compounds.

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Copyright information

© Springer-Verlag New York Inc. 2002