Urological Research

, Volume 27, Issue 5, pp 362–367

Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer

  • Julie Ellerhorst
  • Patricia Troncoso
  • Xiao-Chun Xu
  • Jack Lee
  • Reuben Lotan
ORIGINAL PAPER

DOI: 10.1007/s002400050164

Cite this article as:
Ellerhorst, J., Troncoso, P., Xu, XC. et al. Urological Research (1999) 27: 362. doi:10.1007/s002400050164

Abstract

Galectin-1 and galectin-3, two β-galactoside-binding proteins, have been suggested to play a role in the development and progression of cancer. We have studied the expression of these molecules in normal human prostate tissue and prostate adenocarcinoma. Immunohistochemistry was used to examine formalin-fixed, paraffin-embedded sections of seven normal human prostates, eight cases of prostatic intraepithelial neoplasia (PIN), 20 primary adenocarcinomas of the prostate, and 12 prostate cancer metastases. Galectin-1 was expressed in most cases of all four histologic types. In contrast, galectin-3 expression was significantly decreased in primary carcinoma and metastatic disease compared with normal and premalignant tissue. Galectin-3 expression in primary tumors tended to be less than that of surrounding normal glands. We conclude that loss of galectin-3 expression may be associated with the progression of prostate cancer.

Key words Galectin-1Galectin-3Human prostatecancerImmunohistochemistry

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Julie Ellerhorst
    • 1
  • Patricia Troncoso
    • 3
  • Xiao-Chun Xu
    • 4
  • Jack Lee
    • 5
  • Reuben Lotan
    • 1
  1. 1.Department of Tumor Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USAUS
  2. 2.Department of Melanoma/Sarcoma Box 77, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USAUS
  3. 3.Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USAUS
  4. 4.Department of Clinical Cancer Prevention, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USAUS
  5. 5.Department of Biomathematics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USAUS