Urolithiasis

, Volume 42, Issue 1, pp 45–52

Vitamin D receptor gene (VDR) polymorphisms and the urolithiasis risk: an updated meta-analysis based on 20 case–control studies

  • Wentao Liu
  • Minfeng Chen
  • Mengjun Li
  • Hong Ma
  • Shiyu Tong
  • Ye Lei
  • Lin Qi
Original Paper

DOI: 10.1007/s00240-013-0619-y

Cite this article as:
Liu, W., Chen, M., Li, M. et al. Urolithiasis (2014) 42: 45. doi:10.1007/s00240-013-0619-y

Abstract

Vitamin D receptor (VDR) plays a key role in calcium metabolism, and is closely related to urinary stone formation (urolithiasis). Previous studies have investigated the associations between VDR single nucleotide polymorphisms (SNPs) (polymorphisms at BsmI, ApaI, FokI, or TaqI cutting sites) and urolithiasis in different populations. However, the results remain inconsistent and controversial. Therefore, meta-analysis was performed to evaluate these associations. Twenty studies that investigated the associations between VDR SNPs and urolithiasis were retrieved. Odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated under the most appropriate genetic model. The TaqI polymorphism was associated with an increased risk of urolithiasis (tt + Tt vs. TT: OR = 1.253; 95 % CI = 1.033–1.520, p = 0.022, I2 = 0), whereas the ApaI, BsmI, and FokI polymorphisms were not. Stratifying for ethnicity, a slightly increased risk was found among Asians as compared to Whites (OR 1.263, 1.232, respectively, p < 0.01). Deviation from Hardy–Weinberg equilibrium (HWE) was the major source of heterogeneity. In summary, this updated meta-analysis suggests the TaqI polymorphism is associated with urolithiasis risk, whereas BsmI, ApaI, and FokI polymorphisms are not.

Keywords

Vitamin D receptorPolymorphismsUrolithiasisMeta-analysis

Supplementary material

240_2013_619_MOESM1_ESM.tif (345 kb)
Figure S1 Begg’s funnel plots of TaqI polymorphism and the risk of urinary stones. (TIFF 345 kb)
240_2013_619_MOESM2_ESM.docx (13 kb)
Table S1 The refined criteria for quality assessment. (DOCX 13 kb)
240_2013_619_MOESM3_ESM.docx (14 kb)
Table S2 Summary of meta-analysis results for ApaI polymorphisms. (DOCX 14 kb)
240_2013_619_MOESM4_ESM.docx (14 kb)
Table S3 Summary of meta-analysis results for FokI polymorphism. (DOCX 14 kb)
240_2013_619_MOESM5_ESM.docx (14 kb)
Table S4 Summary of meta-analysis results for TaqI and BsmI polymorphisms. (DOCX 14 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Wentao Liu
    • 1
  • Minfeng Chen
    • 1
  • Mengjun Li
    • 2
  • Hong Ma
    • 3
  • Shiyu Tong
    • 1
  • Ye Lei
    • 1
  • Lin Qi
    • 1
  1. 1.Department of UrologyXiangya Hospital of Central South UniversityChangshaChina
  2. 2.Department of NeurosurgeryThe Second Xiangya Hospital of Central South UniversityChangshaChina
  3. 3.Department of Spine SurgeryThe Second Xiangya Hospital of Central South UniversityChangshaChina