Journal of Molecular Evolution

, Volume 58, Issue 6, pp 653–660

The Decline of Isochores in Mammals: An Assessment of the GC ContentVariation Along the Mammalian Phylogeny

  • Elise M. S. Belle
  • Laurent Duret
  • Nicolas Galtier
  • Adam Eyre-Walker
Article

DOI: 10.1007/s00239-004-2587-x

Cite this article as:
Belle, E.M.S., Duret, L., Galtier, N. et al. J Mol Evol (2004) 58: 653. doi:10.1007/s00239-004-2587-x

Abstract

Whether isochores, the large-scale variation of the GC content in mammalian genomes, are being maintained has recently been questioned. It has been suggested that GC-rich isochores originated in the ancestral amniote genome but that whatever force gave rise to them is no longer effective and that isochores are now disappearing from mammalian genomes. Here we investigated the evolution of the GC content of 41 coding genes in 6 to 66 species of mammals by estimating the ancestral GC content using a method which allows for different rates of substitution between sites. We found a highly significant decrease in the GC content during early mammalian evolution, as well as a weaker but still significant decrease in the GC content of GC-rich genes later in at least three groups of mammals: primates, rodents, and carnivores. These results are of interest because they confirm the recently suggested disappearance of GC-rich isochores in some mammalian genomes, and more importantly, they suggest that this disappearance started very early in mammalian evolution.

Keywords

IsochoreGenomeGC contentNoncoding DNAMammalPrimate

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Elise M. S. Belle
    • 1
  • Laurent Duret
    • 2
  • Nicolas Galtier
    • 3
  • Adam Eyre-Walker
    • 1
  1. 1.Centre for the Study of Evolution—School of Life SciencesUniversity of SussexBrighton BN1 9QGUK
  2. 2.Laboratoire de Biométrie et Biologie évolutiveUMR CNRS 5558, Université Claude Bernard Lyon 1Villeurbanne CedexFrance
  3. 3.Laboratoire Génome, Populations, Interactions, AdaptationsCNRS Université Montpellier 2, IFREMER UMR 5000Montpellier CedexFrance