Article

Journal of Molecular Evolution

, Volume 60, Issue 6, pp 716-725

Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer

  • Aurélien GinolhacAffiliated withLibraGen S.A., Bâtiment Canal Biotech 1Ecologie Microbienne, UMR CNRS 5557, Université Claude Bernard Email author 
  • , Cyrille JarrinAffiliated withLibraGen S.A., Bâtiment Canal Biotech 1Ecologie Microbienne, UMR CNRS 5557, Université Claude Bernard
  • , Patrick RobeAffiliated withLibraGen S.A., Bâtiment Canal Biotech 1
  • , Guy PerrièreAffiliated withLaboratoire de Biométrie et Biologie Évolutive, UMR CNRS 5558, Université Claude Bernard
  • , Timothy M. VogelAffiliated withEcologie Microbienne, UMR CNRS 5557, Université Claude Bernard
  • , Pascal SimonetAffiliated withEcologie Microbienne, UMR CNRS 5557, Université Claude Bernard
  • , Renaud NalinAffiliated withLibraGen S.A., Bâtiment Canal Biotech 1

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Abstract

Type I polyketide synthases (PKSI) are modular multidomain enzymes involved in the biosynthesis of many natural products of industrial interest. PKSI modules are minimally organized in three domains: ketosynthase (KS), acyltransferase (AT), and acyl carrier protein. The KS domain phylogeny of 23 PKSI clusters was determined. The results obtained suggest that many horizontal transfers of PKSI genes have occurred between actinomycetales species. Such gene transfers may explain the homogeneity and the robustness of the actinomycetales group since gene transfers between closely related species could mimic patterns generated by vertical inheritance. We suggest that the linearity and instability of actinomycetales chromosomes associated with their large quantity of genetic mobile elements have favored such horizontal gene transfers.

Keywords

Polyketide synthase Horizontal gene transfer Molecular phylogeny Ketosynthase Actinomycetales