Journal of Molecular Evolution

, Volume 60, Issue 6, pp 716–725

Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer

Authors

    • LibraGen S.A.Bâtiment Canal Biotech 1
    • Ecologie Microbienne, UMR CNRS 5557Université Claude Bernard
  • Cyrille Jarrin
    • LibraGen S.A.Bâtiment Canal Biotech 1
    • Ecologie Microbienne, UMR CNRS 5557Université Claude Bernard
  • Patrick Robe
    • LibraGen S.A.Bâtiment Canal Biotech 1
  • Guy Perrière
    • Laboratoire de Biométrie et Biologie Évolutive, UMR CNRS 5558Université Claude Bernard
  • Timothy M. Vogel
    • Ecologie Microbienne, UMR CNRS 5557Université Claude Bernard
  • Pascal Simonet
    • Ecologie Microbienne, UMR CNRS 5557Université Claude Bernard
  • Renaud Nalin
    • LibraGen S.A.Bâtiment Canal Biotech 1
Article

DOI: 10.1007/s00239-004-0161-1

Cite this article as:
Ginolhac, A., Jarrin, C., Robe, P. et al. J Mol Evol (2005) 60: 716. doi:10.1007/s00239-004-0161-1

Abstract

Type I polyketide synthases (PKSI) are modular multidomain enzymes involved in the biosynthesis of many natural products of industrial interest. PKSI modules are minimally organized in three domains: ketosynthase (KS), acyltransferase (AT), and acyl carrier protein. The KS domain phylogeny of 23 PKSI clusters was determined. The results obtained suggest that many horizontal transfers of PKSI genes have occurred between actinomycetales species. Such gene transfers may explain the homogeneity and the robustness of the actinomycetales group since gene transfers between closely related species could mimic patterns generated by vertical inheritance. We suggest that the linearity and instability of actinomycetales chromosomes associated with their large quantity of genetic mobile elements have favored such horizontal gene transfers.

Keywords

Polyketide synthase Horizontal gene transfer Molecular phylogeny Ketosynthase Actinomycetales

Copyright information

© Springer Science+Business Media, Inc. 2005