Journal of Molecular Evolution

, Volume 59, Issue 1, pp 133–141

Independent Origins of Subgroup Bl+B2 and Subgroup B3Metallo-β-Lactamases

  • Barry G. Hall
  • Stephen J. Salipante
  • Miriam Barlow
Article

DOI: 10.1007/s00239-003-2572-9

Cite this article as:
Hall, B.G., Salipante, S.J. & Barlow, M. J Mol Evol (2004) 59: 133. doi:10.1007/s00239-003-2572-9

Abstract

The metallo-β-lactamases constitute Class B in the Ambler classification of β-lactamases and are divided into three subclasses: Bl, B2, and B3. Bayesian phylogenies of the Subclass B1+B2 and Subclass B3 metallo-β-lactamases and their homologs show that the β-lactam-hydrolyzing function evolved independently within each group. In Subclass B1+B2 that function evolved about 1 billion years ago, and in Subclass B3 it evolved before the divergence of the Gram-positive and Gram-negative eubacteria, about 2 billion years ago. These results lend additional support to the proposal that the metallo-β-lactamases should be divided into two distinct classes.

Keywords

Metallo-β-lactamasesSubgroup B1+B2Subgroup B3Ambler classification

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Barry G. Hall
    • 1
  • Stephen J. Salipante
    • 1
  • Miriam Barlow
    • 1
  1. 1.Biology DepartmentUniversity of RochesterRochesterUSA