, Volume 58, Issue 2, pp 212-217

The Shark HoxN Cluster Is Homologous to the Human HoxD Cluster

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The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.