The Shark HoxN Cluster Is Homologous to the Human HoxD Cluster
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- Prohaska, S.J., Fried, C., Amemiya, C.T. et al. J Mol Evol (2004) 58: 212. doi:10.1007/s00239-003-2545-z
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The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.