Journal of Molecular Evolution

, Volume 58, Issue 2, pp 212–217

The Shark HoxN Cluster Is Homologous to the Human HoxD Cluster

  • Sonja J. Prohaska
  • Claudia Fried
  • Chris T. Amemiya
  • Frank H. Ruddle
  • Günter P. Wagner
  • Peter F. Stadler
Article

DOI: 10.1007/s00239-003-2545-z

Cite this article as:
Prohaska, S.J., Fried, C., Amemiya, C.T. et al. J Mol Evol (2004) 58: 212. doi:10.1007/s00239-003-2545-z

Abstract

The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.

Keywords

Hox clustersPhylogenetic footprints

Copyright information

© Springer-Verlag New York Inc. 2004

Authors and Affiliations

  • Sonja J. Prohaska
    • 1
    • 2
  • Claudia Fried
    • 1
    • 2
  • Chris T. Amemiya
    • 3
  • Frank H. Ruddle
    • 4
  • Günter P. Wagner
    • 5
  • Peter F. Stadler
    • 1
    • 2
    • 6
  1. 1.Bioinformatik, Institut für InformatikUniversität Leipzig, Kreuzstraßse 7b, D-04103 LeipzigGermany
  2. 2.Institut für Theoretische Chemie und Molekulare StrukturbiologieUniversität Wien, Währingerstraße 17, A-1090 WienAustria
  3. 3.Molecular Genetics DepartmentBenaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101USA
  4. 4.Department of Cellular and Developmental BiologyYale University, New Haven, CT 08540USA
  5. 5.Department of Ecology and Evolutionary BiologyYale University, New Haven, CT 08540USA
  6. 6.The Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501USA