Journal of Molecular Evolution

, Volume 58, Issue 1, pp 19–29

Molecular Evolution of FtsZ Protein Sequences Encoded Within the Genomes of Archaea, Bacteria, and Eukaryota

  • Sue Vaughan
  • Bill Wickstead
  • Keith Gull
  • Stephen G. Addinall
Article

DOI: 10.1007/s00239-003-2523-5

Cite this article as:
Vaughan, S., Wickstead, B., Gull, K. et al. J Mol Evol (2004) 58: 19. doi:10.1007/s00239-003-2523-5

Abstract

The FtsZ protein is a polymer-forming GTPase which drives bacterial cell division and is structurally and functionally related to eukaryotic tubulins. We have searched for FtsZ-related sequences in all freely accessible databases, then used strict criteria based on the tertiary structure of FtsZ and its well-characterized invitro and invivo properties to determine which sequences represent genuine homologues of FtsZ. We have identified 225 full-length FtsZ homologues, which we have used to document, phylum by phylum, the primary sequence characteristics of FtsZ homologues from the Bacteria, Archaea, and Eukaryota. We provide evidence for at least five independent ftsZ gene-duplication events in the bacterial kingdom and suggest the existence of three ancestoral euryarchaeal FtsZ paralogues. In addition, we identify “FtsZ-like” sequences from Bacteria and Archaea that, while showing significant sequence similarity to FtsZs, are unlikely to bind and hydrolyze GTP.

Keywords

FtsZTubulinDivisionSeptationCytokinesisGTPaseFtsA

Copyright information

© Springer-Verlag New York Inc. 2004

Authors and Affiliations

  • Sue Vaughan
    • 1
  • Bill Wickstead
    • 1
  • Keith Gull
    • 1
  • Stephen G. Addinall
    • 2
  1. 1.Sir William Dunn School of PathologyUniversity of Oxford, South Parks Road, Oxford OX1 3REUK
  2. 2.University of Manchester, School of Biological Sciences, Oxford Road, Manchester M13 9PTUK