European Journal of Plastic Surgery

, Volume 35, Issue 1, pp 19–24

Histological analysis of capsule formation around silicone implants and comparison with titanium-coated silicone implants in rats

  • Philipp Alexander Bergmann
  • Thomas Lange
  • Frank Siemers
  • Hans-Günther Machens
  • Jörn Andreas Lohmeyer
  • Thomas Namdar
  • Peter Leonhard Stollwerck
  • Stefan Zimmermann
  • Peter Mailänder
Original Paper

DOI: 10.1007/s00238-011-0579-9

Cite this article as:
Bergmann, P.A., Lange, T., Siemers, F. et al. Eur J Plast Surg (2012) 35: 19. doi:10.1007/s00238-011-0579-9

Abstract

Silicone implants have been used for breast augmentation for more than 45 years. Complications, in particular capsular contracture, occur with an incidence of <10% and up to 60%. We investigated the influence of the surface of breast implants on the formation of capsular contracture by comparing silicone with titanium-coated silicone. Seventeen smooth saline-filled silicone (group A) and 14 saline-filled titanium-coated silicone (group B) implants were implanted in female Wistar rats. After 12 and 36 weeks, the implants and capsules were extracted; histological and immunohistochemical staining was performed. The evaluation of the capsules was performed by two examiners in a double-blinded manner. Histologically, no significant difference in total capsule thickness was found. There was a significant difference in synovial-like metaplasia layer (SLM) thickness between groups A and B (p = 0.041). Regarding implantation time (12 vs. 36 weeks), a significant difference was found in SLM thickness (p = 0.021). Immunohistochemical staining indicated a significantly lower infiltration with inflammatory cells in group B. A significant correlation (p = 0.019) between a thick SLM layer and inflammatory cell infiltration was detected. Titanium-coated silicone implants reduce SLM thickness and capsular inflammatory cell infiltration. These findings postulate that titanium-coated silicone implants might point out a new chance in the prevention of capsular contracture.

Keywords

Breast implants Capsular contracture Silicone Augmentation Titanium Biocompatibility 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Philipp Alexander Bergmann
    • 1
  • Thomas Lange
    • 1
  • Frank Siemers
    • 1
  • Hans-Günther Machens
    • 2
  • Jörn Andreas Lohmeyer
    • 2
  • Thomas Namdar
    • 1
  • Peter Leonhard Stollwerck
    • 1
  • Stefan Zimmermann
    • 1
  • Peter Mailänder
    • 1
  1. 1.Plastic Surgery, Hand Surgery, Burn UnitUniversity Hospital Schleswig-Holstein Campus LübeckLübeckGermany
  2. 2.Plastic and Hand SurgeryKlinikum rechts der Isar, Technischen Universität MünchenMunichGermany

Personalised recommendations