Neuroradiology

, Volume 40, Issue 6, pp 398–400

A case of subacute combined degeneration: MRI findings

  • K. Yamada
  • D. A. Shrier
  • H. Tanaka
  • Y. Numaguchi
DIAGNOSTIC NEURORADIOLOGY

DOI: 10.1007/s002340050610

Cite this article as:
Yamada, K., Shrier, D., Tanaka, H. et al. Neuroradiology (1998) 40: 398. doi:10.1007/s002340050610

Abstract

The specific spinal cord lesion caused by vitamin B12 deficiency is known as subacute combined degeneration (SCD). Neuropathological studies of SCD show lesions mainly in the posterior and lateral columns, involving the cortico-spinal and spino-cerebellar tracts. We report a case of SCD in a 19-year-old man who presented with 4 weeks history of gradually progressing tingling in both hands. MRI of the cervical spine demonstrated symmetrical areas of T2 signal abnormality involving the dorsal columns of the cervical cord from the C2 through C5 levels associated with spinal cord expansion. He was treated with vitamin B12 supplements and experienced gradual improvement in his clinical symptoms. Repeat MRI of the cervical spine after 2 months revealed slight decrease in the area of abnormal signal.

Key words SpineCervical spinal cordPosterior columnSubacute combined degenerationVitamin B12 deficiencyDegenerative processMagnetic resonance imaging

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • K. Yamada
    • 1
  • D. A. Shrier
    • 1
  • H. Tanaka
    • 1
  • Y. Numaguchi
    • 1
  1. 1.Department of Diagnostic Radiology, University of Rochester Medical Center, Rochester, New York, USAUS
  2. 2.NMR Center, Massachusetts General Hospital, 13th Streat, Bldg. 149, Charlestown, MA 02129, USA Tel.: +1-617-726-83 13; Fax: +1-617-726-74 22US