Neuroradiology

, Volume 39, Issue 6, pp 427–430

Serial imaging in MELAS

  • A. Miyamoto
  • J. Oki
  • S. Takahashi
  • J. Itoh
  • Y. Kusunoki
  • K. Cho
DIAGNOSTIC NEURORADIOLOGY

DOI: 10.1007/s002340050438

Cite this article as:
Miyamoto, A., Oki, J., Takahashi, S. et al. Neuroradiology (1997) 39: 427. doi:10.1007/s002340050438

Abstract

We report two patients with fatal mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Single-photon emission computed tomography (SPECT) with 123I-N-isopropyl-p-iodoamphetamine was more sensitive to the lesions than CT or MRI. SPECT showed focal hyperperfusion before or during the stroke and diffuse hypoperfusion of the brain, sparing the basal ganglia in the terminal stages. These findings support the theory that metabolic disturbance in the brain causes the “stroke” in MELAS.

Key words Mitochondrial cytopathy MELAS Computed tomography Magnetic resonance imaging Single-photon emission computed tomography 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Miyamoto
    • 1
  • J. Oki
    • 1
  • S. Takahashi
    • 1
  • J. Itoh
    • 1
  • Y. Kusunoki
    • 1
  • K. Cho
    • 1
  1. 1.Department of Pediatrics, Asahikawa Medical College, 4-5-3-11 Nishikagura, Asahikawa 078, JapanJP

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