Neuroradiology

, Volume 43, Issue 8, pp 608–614

Ventricular enlargement in multiple sclerosis: a comparison of three-dimensional and linear MRI estimates

  • B. Turner
  • N. Ramli
  • L. D. Blumhardt
  • T. Jaspan
DIAGNOSTIC NEURORADIOLOGY

DOI: 10.1007/s002340000457

Cite this article as:
Turner, B., Ramli, N., Blumhardt, L. et al. Neuroradiology (2001) 43: 608. doi:10.1007/s002340000457

Abstract

Atrophy of central white matter is related to irreversible clinical disability in multiple sclerosis (MS) and ventricular enlargement may be a sensitive marker of this tissue loss. Therapeutic trials in MS have provided MRI data for investigation of cerebral atrophy in MS. These studies use almost exclusively two-dimensional (2-D) images, which may be limited in the assessment of three-dimensional (3-D) structures. We used 3-D MRI data to estimate ventricular volumes in 40 patients with MS and 10 healthy controls, to look at associations with clinical disability and the stage of the disease. We then compared simple linear measures of ventricular size from conventional 2-D images, with 3-D volume estimates to establish the best available linear indices of ventricular volume. Mean ventricular volumes were increased in the patients and significantly larger in the more disabled patients. The estimated volume of the third ventricle obtained from 3-D MRI showed the strongest association with the clinical stage of the disease, duration of symptoms and levels of disability. Finally, we confirmed that in patients with MS accurate data on ventricular size can be obtained from 2-D images by two simple and convenient linear measures, the width of the third ventricle and of the anterior horn of the lateral ventricle.

Keywords Multiple sclerosisCerebral atrophyCerebral ventriclesMagnetic resonance imaging

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • B. Turner
    • 1
  • N. Ramli
    • 2
  • L. D. Blumhardt
    • 1
  • T. Jaspan
    • 3
  1. 1.Division of Clinical Neurology, B Floor, Medical School, University Hospital, Queen's Medical Centre, Nottingham, NG9 2SN, UK e-mail: nnzldb@nnn1.med.nottingham.ac.uk Tel.: + 44-1 15-9 24 99 24 Fax: + 44-1 15-9 70 97 38GB
  2. 2.Department of Radiology, University Hospital Kuala Lumpur, Kuala Lumpur, Malaysia 59100MY
  3. 3.Department of Radiology, University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH, UKGB