Neuroradiology

, Volume 56, Issue 2, pp 97–106

Diffusion tensor tractography and neuropsychological assessment in patients with vitamin B12 deficiency

Authors

  • Pradeep Kumar Gupta
    • Department of NeurologyKing George’s Medical University
    • Department of NeurologyKing George’s Medical University
  • Rakesh Kumar Gupta
    • Departments of Radiology and ImagingFortis Memorial Research Institute
  • Hardeep Singh Malhotra
    • Department of NeurologyKing George’s Medical University
  • Vimal Kumar Paliwal
    • Department of NeurologySanjay Gandhi Postgraduate Institute of Medical Sciences
  • Ram Kishore Singh Rathore
    • Department of Mathematics and StatisticsIndian Institute of Technology
  • Rajesh Verma
    • Department of NeurologyKing George’s Medical University
  • Maneesh Kumar Singh
    • Department of NeurologyKing George’s Medical University
  • Yogita Rai
    • Department of RadiodiagnosisSanjay Gandhi Postgraduate Institute of Medical Sciences
  • Chandra Mani Pandey
    • Department of BiostatisticsSanjay Gandhi Postgraduate Institute of Medical Sciences
Diagnostic Neuroradiology

DOI: 10.1007/s00234-013-1306-y

Cite this article as:
Gupta, P.K., Garg, R.K., Gupta, R.K. et al. Neuroradiology (2014) 56: 97. doi:10.1007/s00234-013-1306-y

Abstract

Introduction

Structural imaging of the brain does not demonstrate any changes in a vast majority of patients with vitamin B12 deficiency, even in advanced stages. In this study, we aimed to assess and correlate the functional integrity of the brain fiber tracts using diffusion tensor tractography with neuropsychological examination in patients with vitamin B12 deficiency.

Methods

The study was conducted at two tertiary care centers. Thirty-two patients with vitamin B12 deficiency were enrolled and subjected to diffusion tensor tractography, as an extension of diffusion tensor imaging, and neuropsychological assessment. Tests of significance were done to detect changes, pre- and post-vitamin B12 supplementation in the diffusivity parameters (fractional anisotropy and mean diffusivity) and the neuropsychological test scores.

Results

Statistically significant changes were observed in the diffusivity parameters and the neuropsychological test scores between the controls and the patients with vitamin B12deficiency in the pre- and post-treatment phases.

Conclusions

This is the first study to evaluate the diffusion tensor tractography (DTT) parameters in the light of clinical neuropsychological assessment in patients with vitamin B12 deficiency. Utilization of DTT parameters may antedate structural changes and may quantify the neurocognitive deficits.

Keywords

Magnetic resonance imagingDiffusion tensor imagingDiffusion tensor tractographyFolic acidCognition

Copyright information

© Springer-Verlag Berlin Heidelberg 2013