Neuroradiology

, Volume 55, Issue 6, pp 655–674

Cerebral microbleeds: a guide to detection and clinical relevance in different disease settings

  • Andreas Charidimou
  • Anant Krishnan
  • David J. Werring
  • H. Rolf Jäger
CONTINUING EDUCATION

DOI: 10.1007/s00234-013-1175-4

Cite this article as:
Charidimou, A., Krishnan, A., Werring, D.J. et al. Neuroradiology (2013) 55: 655. doi:10.1007/s00234-013-1175-4

Abstract

Cerebral microbleeds have emerged as an important new imaging marker of cerebral small vessel disease. With the development of MRI techniques that are exquisitely sensitive to paramagnetic blood products, such as T2*-weighted gradient-recalled echo and susceptibility-weighted sequences, microbleeds have been detected in ever-increasing numbers of patients in stroke and cognitive clinics, as well as in healthy older people and in a variety of other rarer diseases and syndromes. Detection of cerebral microbleeds has clinical implications with respect to the diagnosis of the underlying small vessel disease, the safety of antithrombotic use, and the risk of symptomatic intracerebral haemorrhage, cognitive impairment and dementia. This article provides a guide to the detection and clinical relevance of cerebral microbleeds in different conditions based on a comprehensive review of the literature and own findings in research and clinical practice.

Keywords

Cerebral microbleedsCerebral small vessel diseaseSusceptibility-weighted imagingCerebral amyloid angiopathyIntracerebral haemorrhage

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Andreas Charidimou
    • 1
  • Anant Krishnan
    • 2
  • David J. Werring
    • 1
  • H. Rolf Jäger
    • 2
    • 3
    • 4
  1. 1.Stroke Research Group, UCL Institute of NeurologyThe National Hospital for Neurology and NeurosurgeryLondonUK
  2. 2.Lysholm Department of NeuroradiologyThe National Hospital for Neurology and NeurosurgeryLondonUK
  3. 3.Department of Brain Repair and RehabilitationUCL Institute of NeurologyLondonUK
  4. 4.UCL Institute of Neurology. The National Hospital for Neurology and NeurosurgeryUniversity College Hospital (UCH)LondonUK