Neuroradiology

, Volume 55, Issue 2, pp 179–185

Intracranial carotid artery disease in patients with recent neurological symptoms: high prevalence on CTA

  • Henk A. Marquering
  • Paul J. Nederkoorn
  • Leslie Bleeker
  • René van den Berg
  • Charles B. Majoie
Diagnostic Neuroradiology

DOI: 10.1007/s00234-012-1097-6

Cite this article as:
Marquering, H.A., Nederkoorn, P.J., Bleeker, L. et al. Neuroradiology (2013) 55: 179. doi:10.1007/s00234-012-1097-6

Abstract

Introduction

Novel postprocessing techniques have enabled accurate quantification of intracranial carotid atherosclerotic disease on CT Angiography (CTA). Our purpose was to estimate the prevalence of intracranial carotid artery disease, i.e., stenosis and calcium, on CTA in patients with recent neurological symptoms.

Methods

The degree of stenosis and calcium volume of 162 extracranial and intracranial internal carotid arteries (ICAs) was quantitatively measured on CTA images of 88 consecutive patients with recent neurological symptoms and extracranial ICA stenosis as screened by ultrasound. The prevalence of intracranial ICA stenosis and presence of calcium was estimated and correlated with extracranial ICA stenosis.

Results

Intracranial ICA stenosis was observed in 83 % (95 %CI: 77–89 %) and 39 % (95 %CI: 31–47 %) for a stenosis of ≥30 % and ≥50 %, respectively. Only on the symptomatic side, a statistical significant correlation between intracranial and extracranial stenoses was observed (Pearson's r 0.32, P = 0.006). In the 37 arteries with an extracranial ICA stenosis of ≥70 %, 89 % (95 %CI: 79–99 %) and 46 % (95 %CI: 30–62 %) of the intracranial ICA showed a stenosis of ≥30 % and ≥50 %, respectively.

Conclusion

In our population of patients with recent neurological symptoms and extracranial stenosis as screened by ultrasound, CTA imaging resulted in a substantially higher prevalence of intracranial ICA disease than previously reported. This remarkably high prevalence of intracranial ICA disease on CTA may have important future implications for acute and preventive treatment strategies.

Keywords

Intracranial arteryStenosisCTAPrevalenceAcute ischemic stroke

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Henk A. Marquering
    • 1
    • 2
  • Paul J. Nederkoorn
    • 3
  • Leslie Bleeker
    • 1
  • René van den Berg
    • 1
  • Charles B. Majoie
    • 1
  1. 1.Department of RadiologyAMCAmsterdamThe Netherlands
  2. 2.Department of Biomedical Engineering & PhysicsAMCAmsterdamThe Netherlands
  3. 3.Department of NeurologyAMCAmsterdamThe Netherlands