Neuroradiology

, Volume 54, Issue 12, pp 1303–1312

Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients - A position paper endorsed by ESMINT and ESNR

Part II: methodology of future trials
  • Jens Fiehler
  • Michael Söderman
  • Francis Turjman
  • Philip M. White
  • Søren Jacob Bakke
  • Salvatore Mangiafico
  • Rüdiger von Kummer
  • Mario Muto
  • Christophe Cognard
  • Jan Gralla
Invited Review

DOI: 10.1007/s00234-012-1076-y

Cite this article as:
Fiehler, J., Söderman, M., Turjman, F. et al. Neuroradiology (2012) 54: 1303. doi:10.1007/s00234-012-1076-y

Abstract

Based on current data and experience, the joint working group of the European Society of Minimally Invasive Neurological Therapy (ESMINT) and the European Society of Neuroradiology (ESNR) make suggestions on trial design and conduct aimed to investigate therapeutic effects of mechanical thrombectomy (MT). We anticipate that this roadmap will facilitate the setting up and conduct of successful trials in close collaboration with our neighbouring disciplines.

Keywords

StrokeInterventional neuroradiologyThrombectomyThrombolysis

Abbreviations

ASPECTS

Alberta Stroke Program Early CT

BCO

Balloon guiding catheter occlusion

BMT

Best medical therapy

CAS

Carotid stenting

CBF

Cerebral blood flow

CBV

Cerebral blood volume

CCA

Common carotid artery

CEA

Carotid endarterectomy

CS

Conscious sedation

CTA

CT-angiography

CTP

CT-perfusion

DSA

Digital subtraction angiography

DWI

Diffusion weighted imaging

EIC

Early ischemic signs

ESMINT

European Society of Minimally Invasive Neurological Therapy

ESNR

European Society of Neuroradiology

ESO

European Stroke Organisation

FU

Follow up

GA

General anaesthesia

ICA

Internal carotid artery

IMS III

Interventional Management of Stroke III Trial

IVT

Intravenous thrombolytical therapy

MCA

Middle cerebral artery

mRS

Modified rankin scale

MT

Mechanical thrombectomy

NE-CT

Non-enhanced CT

NIH-SS

National Institute of Health Stroke Scale

PI

Perfusion MRI

RCT

Randomised control trial

sICH

Symptomatic intracranial haemorrhage

stent-triever

Self-expanding stents

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Jens Fiehler
    • 1
  • Michael Söderman
    • 2
  • Francis Turjman
    • 3
  • Philip M. White
    • 4
  • Søren Jacob Bakke
    • 5
  • Salvatore Mangiafico
    • 6
  • Rüdiger von Kummer
    • 7
  • Mario Muto
    • 8
  • Christophe Cognard
    • 9
  • Jan Gralla
    • 10
  1. 1.Department of NeuroradiologyUniversity Medical Centre Hamburg-EppendorfHamburgGermany
  2. 2.Department of NeuroradiologyKarolinska University HospitalStockholmSweden
  3. 3.Department of NeuroradiologyHôpital neurologique, Centre de Neurosciences CognitivesLyonFrance
  4. 4.Department of Clinical Neurosciences, Western General HospitalUniversity of EdinburghEdinburghUK
  5. 5.Department of NeuroradiologyOslo University HospitalOsloNorway
  6. 6.Interventional Neuroradiology UnitUniversity Hospital CareggiFlorenceItaly
  7. 7.Department of NeuroradiologyUniversity of DresdenDresdenGermany
  8. 8.Department of NeuroradiologyUniversity of NaplesNaplesItaly
  9. 9.Service de NeuroradiologieHôpital PurpanToulouseFrance
  10. 10.Department of NeuroradiologyInselspital BernBernSwitzerland