Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
We aimed to assess the relationship between atherosclerotic carotid plaque composition analyzed using multidetector computed tomography (MDCT) and the appearance of new ischemic lesions detected by diffusion-weighted images (DWI) after carotid artery stenting (CAS).
We quantitatively and qualitatively analyzed plaque characteristics in carotid arteries using MDCT before CAS in 19 patients. Carotid plaques were expediently subdivided into four components with Hounsfield unit (HU) values of <0, 0–60, 60–130, and >600. The incidence of distal embolism was evaluated with DWI. Pearson's correlation analyses were used to assess the association between plaque composition and the incidence of cerebral embolization.
Fifteen patients (79%) demonstrated new DWI lesions after CAS. High-signal DWIs were noted as follows: one in six patients, 2 ~ 5 in five patients, 6 ~ 10 in two patients, and >10 in two patients. The mean volumes of the plaque components for HU < 0, 0–60, 60–130, and >600 were 5.4, 200, 260, and 59 mm3, respectively. There was a strong correlation between the number of high-signal DWI lesions in the ipsilateral side and the plaque volume of HU < 0 (r = 0.927; P < 0.0001). There was a moderate correlation between the number of high-signal DWI lesions and the plaque volume of HU 0–60 (r = 0.568; P = 0.0099) and the sum total of HU < 0 and HU 0–60 (r = 0.609; P = 0.0047).
Quantitative and qualitative tissue characterization of carotid plaques using MDCT might be a useful predictor for silent ischemic lesions after CAS.
- Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting
Volume 54, Issue 5 , pp 487-493
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Carotid plaque
- Carotid stenting
- Diffusion-weighted imaging
- Distal embolism
- Multidetector computed tomography
- Industry Sectors
- Author Affiliations
- 1. Department of Neurosurgery and Radiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
- 2. Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan