, Volume 54, Issue 2, pp 113–121

Factors affecting brain structure in men with HIV disease in the post-HAART era


    • Department of PsychiatryUniversity of Pittsburgh School of Medicine
    • Department of NeurologyUniversity of Pittsburgh School of Medicine
    • Department of PsychologyUniversity of Pittsburgh School of Medicine
    • Neuropsychology Research Program
  • Victoria Maruca
    • Spalding University
  • Lawrence A. Kingsley
    • Department of Infectious Diseases and Microbiology, Graduate School of Public HealthUniversity of Pittsburgh
  • Joanne M. Sanders
    • Department of Epidemiology, Bloomberg School of Public HealthThe Johns Hopkins University
  • Jeffery R. Alger
    • Department of NeurologyUniversity of California Los Angeles
  • Peter B. Barker
    • Department of RadiologyThe Johns Hopkins University School of Medicine
  • Karl Goodkin
    • Neuropsychiatric InstituteUniversity of California Los Angeles
  • Eileen Martin
    • Department of PsychiatryUniversity of Illinois at Chicago
  • Eric N. Miller
    • Neuropsychiatric InstituteUniversity of California Los Angeles
  • Ann Ragin
    • Department of NeurologyFeinberg School of Medicine, Northwestern University
  • Ned Sacktor
    • Department of NeurologyThe Johns Hopkins University School of Medicine
  • Ola Selnes
    • Department of NeurologyThe Johns Hopkins University School of Medicine
  • for the Multicenter AIDS Cohort Study
Diagnostic Neuroradiology

DOI: 10.1007/s00234-011-0854-2

Cite this article as:
Becker, J.T., Maruca, V., Kingsley, L.A. et al. Neuroradiology (2012) 54: 113. doi:10.1007/s00234-011-0854-2



The purpose of this study was to characterize brain volumetric differences in HIV seropositive and seronegative men and to determine effects of age, cardiovascular risk, and HIV infection on structural integrity.


Magnetic resonance imaging was used to acquire high-resolution neuroanatomic data in 160 men aged 50 years and over, including 84 HIV seropositive and 76 seronegative controls. Voxel-based morphometry was used to derive volumetric measurements at the level of the individual voxel. Data from a detailed neuropsychological test battery were recombined into four summary scores representing psychomotor speed, visual memory, verbal memory, and verbal fluency.


Both age and HIV status had a significant effect on both gray matter (GM) and white matter (WM) volume. The age-related GM atrophy was primarily in the superior temporal and inferior frontal regions; the HIV-related GM loss included the posterior and inferior temporal lobes, the parietal lobes, and the cerebellum. Among all subjects, the performance on neuropsychological tests, as indexed by a summary variable, was related to the volume of both the GM and WM. Contrary to our predictions, the CVD variables were not linked to brain volume in statistically adjusted models.


In the post-HAART era, having HIV infection is still linked to atrophy in both GM and WM. Secondly, advancing age, even in this relatively young cohort, is also linked to changes in GM and WM volume. Thirdly, CNS structural integrity is associated with overall cognitive functions, regardless of the HIV infection status of the study volunteers.


MRICognitionHIVAgeVoxel-based morphometry

Supplementary material

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Fig. E-1

(GIF 142 kb)

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High resolution image file (TIFF 346 kb)

Copyright information

© Springer-Verlag 2011