Neuroradiology

, Volume 53, Issue 4, pp 261–266

Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke

Authors

    • Calgary Stroke ProgramUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
  • Michael D. Hill
    • Calgary Stroke ProgramUniversity of Calgary
    • Hotchkiss Brain InstituteUniversity of Calgary
    • Department of RadiologyUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
  • Muneer Eesa
    • Department of RadiologyUniversity of Calgary
  • Jayesh Modi
    • Department of RadiologyUniversity of Calgary
  • Rohit Bhatia
    • Calgary Stroke ProgramUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
  • John Wong
    • Hotchkiss Brain InstituteUniversity of Calgary
    • Department of RadiologyUniversity of Calgary
    • Department of NeurosurgeryUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
  • Mark E. Hudon
    • Hotchkiss Brain InstituteUniversity of Calgary
    • Department of RadiologyUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
  • Will Morrish
    • Hotchkiss Brain InstituteUniversity of Calgary
    • Department of RadiologyUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
  • Andrew M. Demchuk
    • Calgary Stroke ProgramUniversity of Calgary
    • Hotchkiss Brain InstituteUniversity of Calgary
    • Department of RadiologyUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
  • Mayank Goyal
    • Hotchkiss Brain InstituteUniversity of Calgary
    • Department of RadiologyUniversity of Calgary
    • Department of Clinical NeurosciencesUniversity of Calgary
Interventional Neuroradiology

DOI: 10.1007/s00234-010-0725-2

Cite this article as:
Menon, B.K., Hill, M.D., Eesa, M. et al. Neuroradiology (2011) 53: 261. doi:10.1007/s00234-010-0725-2

Abstract

Introduction

The Penumbra system is a newly approved mechanical device for the treatment of acute stroke designed for better and faster recanalization. We describe our initial experience with the use of this device.

Methods

We studied 27 consecutive patients with acute ischemic strokes due to arterial occlusions presenting at our center from January to October 2009. The primary outcome was the degree of recanalization measured by thrombolysis in myocardial infarction (TIMI grade 2/3) at the end of the procedure. Secondary end points were the proportion of patients who achieved a modified Rankin scale (mRS) ≤2 at 3 months, all-cause mortality and intracerebral hemorrhage (ICH) on non contrast computed tomography at 24 h. Procedural complications were also recorded.

Results

Of 27 patients (13 male, mean age 61 years) in the study, 22 (81%) patients had anterior circulation strokes and five (18%) had posterior circulation strokes. Twenty-three (85%) patients achieved TIMI grade 2/3 recanalization at completion of the procedure. Excluding five patients who needed use of a second device, the Penumbra system achieved TIMI grade 2/3 recanalization in 67% of patients. Thirteen (48%) patients had mRS ≤2 at 3-month follow-up. Procedural and post-procedural complications included vasospasm (3.7%), distal emboli (48.1%), and ICH (33.3%). The distribution of ICH is as follows: hemorrhagic infarct type 1 (25.9%), parenchymal hemorrhage type 1 (3.7%), and parenchymal hemorrhage type 2 (3.7%). All-cause mortality was 19%.

Conclusions

High recanalization rates and good clinical outcomes are achievable with the Penumbra system. Complication rates are comparable to a previously published literature.

Keywords

Penumbra systemEndovascular interventionAcute ischemic stroke

Copyright information

© Springer-Verlag 2010