Neuroradiology

, Volume 52, Issue 1, pp 15–24

Neuroimaging after coma

  • Luaba Tshibanda
  • Audrey Vanhaudenhuyse
  • Mélanie Boly
  • Andrea Soddu
  • Marie-Aurelie Bruno
  • Gustave Moonen
  • Steven Laureys
  • Quentin Noirhomme
Invited Review

DOI: 10.1007/s00234-009-0614-8

Cite this article as:
Tshibanda, L., Vanhaudenhuyse, A., Boly, M. et al. Neuroradiology (2010) 52: 15. doi:10.1007/s00234-009-0614-8

Abstract

Following coma, some patients will recover wakefulness without signs of consciousness (only showing reflex movements, i.e., the vegetative state) or may show non-reflex movements but remain without functional communication (i.e., the minimally conscious state). Currently, there remains a high rate of misdiagnosis of the vegetative state (Schnakers et. al. BMC Neurol, 9:35, 8) and the clinical and electrophysiological markers of outcome from the vegetative and minimally conscious states remain unsatisfactory. This should incite clinicians to use multimodal assessment to detect objective signs of consciousness and validate para-clinical prognostic markers in these challenging patients. This review will focus on advanced magnetic resonance imaging (MRI) techniques such as magnetic resonance spectroscopy, diffusion tensor imaging, and functional MRI (fMRI studies in both “activation” and “resting state” conditions) that were recently introduced in the assessment of patients with chronic disorders of consciousness.

Keywords

Vegetative stateDiffusion tensor imagingMR spectroscopyFunctional MRIConsciousness

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Luaba Tshibanda
    • 1
    • 2
  • Audrey Vanhaudenhuyse
    • 1
  • Mélanie Boly
    • 1
    • 2
    • 3
  • Andrea Soddu
    • 1
  • Marie-Aurelie Bruno
    • 1
  • Gustave Moonen
    • 3
  • Steven Laureys
    • 1
    • 2
    • 3
  • Quentin Noirhomme
    • 1
  1. 1.Coma Science Group, Cyclotron Research CenterUniversity and University Hospital of LiègeLiègeBelgium
  2. 2.Department of NeuroradiologyUniversity Hospital of LiègeLiègeBelgium
  3. 3.Department of NeurologyUniversity Hospital of LiègeLiègeBelgium