Neuroradiology

, Volume 47, Issue 11, pp 805–808

Cortical T2 signal shortening in amyotrophic lateral sclerosis is not due to iron deposits

Authors

    • Department of NeurologyUniversity of Erlangen-Nuremberg
  • C. Fellner
    • Institute of Diagnostic RadiologyUniversity of Erlangen-Nuremberg
    • Institute of RadiologyLandes-Nervenklinik Wagner-Jauregg
  • A. Schmid
    • Institute of Diagnostic RadiologyUniversity of Erlangen-Nuremberg
  • B. Neundörfer
    • Department of NeurologyUniversity of Erlangen-Nuremberg
  • F. A. Fellner
    • Institute of Diagnostic RadiologyUniversity of Erlangen-Nuremberg
    • Institute of RadiologyLandes-Nervenklinik Wagner-Jauregg
Diagnostic Neuroradiology

DOI: 10.1007/s00234-005-1421-5

Cite this article as:
Hecht, M.J., Fellner, C., Schmid, A. et al. Neuroradiology (2005) 47: 805. doi:10.1007/s00234-005-1421-5

Abstract

Signal shortening of the motor cortex in T2-weighted MR images is a frequent finding in patients with amyotrophic lateral sclerosis (ALS). The cause of signal shortening in ALS is unknown, although iron deposits have been suggested. To test this hypothesis, we acquired T2*-weighted gradient-echo (GRE) MR images in addition to T2-weighted turbo spin-echo in 69 patients with ALS. Signal shortening in T2-weighted images was found in 31 patients. In T2*-weighted GRE images, only three patients had signal shortening. One patient with additional bifrontal haemorrhage had frontal but no motor cortex signal shortening. Iron deposits do not cause cortical signal shortening in patients with ALS predominantly. Other factors are presumably more important in the generation of cortical T2 shortening in ALS.

Keywords

Amyotrophic lateral sclerosisMagnetic resonance imagingT2 signal shorteningT2*-weighted gradient echoIron

Copyright information

© Springer-Verlag 2005