Neuroradiology

, Volume 48, Issue 1, pp 50–53

Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: preliminary report of two cases

  • S. Suzuki
  • O. Ito
  • T. Sayama
  • S. Yamaguchi
  • K. Goto
  • T. Sasaki
Interventional Neuroradiology

DOI: 10.1007/s00234-005-0014-7

Cite this article as:
Suzuki, S., Ito, O., Sayama, T. et al. Neuroradiology (2006) 48: 50. doi:10.1007/s00234-005-0014-7

Abstract

We describe two patients with symptomatic vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin daropate hydrochloride (HCl). Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated intracellular concentrations of cyclic adenosine monophosphate. We suggest that colforsin daropate HCl might be a useful therapeutic tool in treating cerebral vasospasm.

Keywords

AneurysmColforsin daropateSubarachnoid hemorrhageVasospasm

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • S. Suzuki
    • 1
    • 4
  • O. Ito
    • 1
    • 2
  • T. Sayama
    • 1
  • S. Yamaguchi
    • 1
    • 2
  • K. Goto
    • 2
  • T. Sasaki
    • 3
  1. 1.Department of Neurological SurgeryShin-Koga HospitalKurumeJapan
  2. 2.Department of Interventional NeuroradiologyShin-Koga HospitalKurumeJapan
  3. 3.Department of NeurosurgeryKyushu University Graduate School of MedicineFukuokaJapan
  4. 4.Department of NeurosurgeryNippon Steel Yawata Memorial HospitalKitakyushuJapan