Diffusion of water in large demyelinating lesions: a follow-up study
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- Castriota-Scanderbeg, A., Sabatini, U., Fasano, F. et al. Neuroradiology (2002) 44: 764. doi:10.1007/s00234-002-0806-y
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We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1–36 months. The orientationally averaged diffusion coefficient <D> was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between <D> and the degree of low signal on T1-weighted images. The quantitative information provided by <D> allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.