The Journal of Membrane Biology

, 209:89

Hair Cells – Beyond the Transducer

  • G.D. Housley
  • W. Marcotti
  • D. Navaratnam
  • E.N. Yamoah

DOI: 10.1007/s00232-005-0835-7

Cite this article as:
Housley, G., Marcotti, W., Navaratnam, D. et al. J Membrane Biol (2006) 209: 89. doi:10.1007/s00232-005-0835-7


This review considers the “tween twixt and twain” of hair cell physiology, specifically the signaling elements and membrane conductances which underpin forward and reverse transduction at the input stage of hair cell function and neurotransmitter release at the output stage. Other sections of this review series outline the advances which have been made in understanding the molecular physiology of mechanoelectrical transduction and outer hair cell electromotility. Here we outline the contributions of a considerable array of ion channels and receptor signaling pathways that define the biophysical status of the sensory hair cells, contributing to hair cell development and subsequently defining the operational condition of the hair cells across the broad dynamic range of physiological function.


Inner hair cellOuter hair cellVestibularPotassium channelsEfferentKCaBK channelP2X receptorP2Y receptorCochleaOntogenyNoiseNeurotransmissionHair cell tuningAcetylcholineDopamineOlivocochlear bundleKCNQ4Calcium channelsReview

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • G.D. Housley
    • 1
  • W. Marcotti
    • 2
  • D. Navaratnam
    • 3
  • E.N. Yamoah
    • 4
  1. 1.Department of PhysiologyUniversity of AucklandPrivate BagNew Zealand
  2. 2.Department of Biomedical Science, Addison BuildingUniversity of SheffieldWestern BankUK
  3. 3.Department of NeurobiologyYale University, School of MedicineNew HavenUSA
  4. 4.Department of Otolaryngology, Center for NeuroscienceUniversity of California, Davis, School of MedicineUSA