Optimal-Sensitivity Analysis of Ion Channel Gating Kinetics
Received: 23 December 2003 Revised: 25 March 2004 DOI:
Cite this article as: Kargol, A. & Hosein-Sooklal, A. J Membrane Biol (2004) 199: 113. doi:10.1007/s00232-004-0681-z Abstract
We propose a new approach to analysis of kinetic models for ion channel gating, based on application of fluctuating voltages through a voltage clamp, in addition to conventional techniques. We show that the channel kinetics can be probed in a much more sensitive way, leading to more efficient model selection and more reliable estimates of model parameters. We use wavelet transform as an analytic tool for fluctuating currents and parametric dispersion plots as a measure of model compatibility with experimental data.
Keywords Voltage-gated ion channels Markov models Nonequilibrium response spectroscopy Wavelets
This revised version was published online in August 2005 with a corrected cover date.
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